PATHOLOGICAL ASPECTS OF A NEWLY DESCRIBED NEPHROPATHY RELATED TO THE PROLONGED USE OF CHINESE HERBS
PATHOLOGICAL ASPECTS OF A NEWLY DESCRIBED NEPHROPATHY RELATED TO THE PROLONGED USE OF CHINESE HERBS
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DOI：
10.1016/s0272-6386(12)80178-8
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发表时间：
1994-08-01
影响因子：
13.2
通讯作者：
VANHERWEGHEM, JL
中科院分区：
文献类型：
--
作者：
DEPIERREUX, M;VANDAMME, B;VANHERWEGHEM, JL
最近在比利时发现的一种慢性肾间质纤维化的新病因，被发现与包括中草药在内的减肥方案有关。我们讨论了三十三例活检证实的这种肾病的病例，并特别提到了病理方面。广泛间质纤维化伴小管萎缩和丧失是主要病变；它主要位于浅表皮层。肾小球相对完好。尽管如此，他们还是表现出轻微的毛细血管塌陷和基底膜起皱。鲍曼囊增厚是规律。由于内皮细胞肿胀，小叶间和传入小动脉壁增厚。这些方面提示原发性病变可能位于血管壁，导致缺血和间质纤维化。另一方面，它们的特征足以让病理学家怀疑诊断，即使没有摄取中草药的记忆。
A new cause of chronic interstitial fibrosis of the kidney, recently identified in Belgium, was found to be related to a slimming regimen that included Chinese herbs. Thirty-three biopsy-proven cases of this nephropathy are discussed, with special reference to the pathologic aspects. Extensive interstitial fibrosis with atrophy and loss of the tubules was the major lesion; it was predominantly located in the superficial cortex. The glomeruli were relatively spared. They nevertheless showed a mild collapse of the capillaries and wrinkling of the basement membrane. Thickening of Bowman's capsule was the rule. Interlobular and afferent arterioles showed thickening of their walls due to swelling of the endothelial cells. These aspects suggest that the primary lesions could be located in the vessel walls, leading to ischemia and interstitial fibrosis. On the other hand, they are characteristic enough to allow the pathologist to suspect the diagnosis even in the absence of an anamnesis of ingestion of Chinese herbs.