Analysis of Tie2-Expressing Monocytes (TEM) in Patients With Colorectal Cancer
Analysis of Tie2-Expressing Monocytes (TEM) in Patients With Colorectal Cancer
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DOI：
10.3109/07357907.2011.636114
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发表时间：
2012-03-01
影响因子：
2.4
通讯作者：
Hacker, Ulrich T.
中科院分区：
文献类型：
--
作者：
Goede, Valentin;Coutelle, Oliver;Hacker, Ulrich T.
表达 Tie2 的单核细胞 (TEM) 在实验癌症模型中促进肿瘤血管生成和生长。 TEM 在癌症患者中的作用尚不清楚。我们研究了健康志愿者和结直肠癌 (CRC) 患者的 TEM。尽管在 CRC 患者的血液和肿瘤病变中可检测到 TEM，但其频率和功能表型与血管生成素 2 或血管内皮生长因子的水平、微血管密度、肿瘤标志物、肿瘤分期或抗血管生成治疗的结果没有相关性。这些意外的发现与小鼠肿瘤模型不一致，并质疑 TEM 在人类癌症中的诊断或治疗价值。
Tie2-expressing monocytes (TEM) promote tumor angiogenesis and growth in experimental cancer models. The role of TEM in cancer patients is unknown. We studied TEM in healthy volunteers and colorectal cancer (CRC) patients. Although TEM were detectable in the blood and tumor lesions of CRC patients, their frequency and functional phenotype showed no correlation with levels of angiopoietin-2 or vascular endothelial growth factor, microvessel density, tumor markers, tumor stage, or outcome of antiangiogenic therapy. These unexpected findings are at odds with murine tumor models and question the diagnostic or therapeutic value of TEM in human cancer.