Magnetic resonance of a dextran-coated magnetic fluid intravenously administered in mice
Magnetic resonance of a dextran-coated magnetic fluid intravenously administered in mice
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DOI：
10.1016/s0006-3495(01)76217-0
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发表时间：
2001-05-01
影响因子：
3.4
通讯作者：
Morais, PC
中科院分区：
文献类型：
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作者：
Lacava, LM;Lacava, ZGM;Morais, PC
磁共振被用来调查磁铁矿纳米粒子（9.4 nm的核心直径）的动力学处置后，静脉注射磁铁矿为基础的葡聚糖涂层的磁性流体在雌性瑞士小鼠的血液循环。在第一个60分钟的血液循环中的纳米颗粒浓度的时间衰减遵循一个指数（一室）模型与半衰期（6.9 +/- 0.7）分钟。X-带光谱显示一个广泛的单线在g接近2，典型的纳米磁性颗粒悬浮在一个磁性基质。随着粒子浓度的降低，共振场向更高的值移动，遵循两个不同的制度。在较高浓度区（10（14）cm（-3）以上），粒子-粒子相互作用响应于非线性行为，而在较低浓度区（10（14）cm（-3）以下），粒子-粒子相互作用被排除，系统仅由于退磁场效应而恢复线性。
Magnetic resonance was used to investigate the kinetic disposition of magnetite nanoparticles (9.4 nm core diameter) from the blood circulation after intravenous injection of magnetite-based dextran-coated magnetic fluid in female Swiss mice. In the first 60 min the time-decay of the nanoparticle concentration in the blood circulation follows the one-exponential (one-compartment) model with a half-life of (6.9 +/- 0.7) min. The X-band spectra show a broad single line at g approximate to 2, typical of nanomagnetic particles suspended in a nonmagnetic matrix. The resonance field shifts toward higher values as the particle concentration reduces, following two distinct regimes. At the higher concentration regime (above 10(14) cm(-3)) the particle-particle interaction responds for the nonlinear behavior, while at the lower concentration regime (below 10(14) cm(-3)) the particle-particle interaction is ruled out and the system recovers the linearity due to the demagnetizing field effect alone.