OPIATE MODULATION OF SEPARATION-INDUCED DISTRESS IN NON-HUMAN PRIMATES
OPIATE MODULATION OF SEPARATION-INDUCED DISTRESS IN NON-HUMAN PRIMATES
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DOI：
10.1016/0006-8993(88)90997-3
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发表时间：
1988-02-09
期刊：
影响因子：
2.9
通讯作者：
BARKSDALE, CM
中科院分区：
文献类型：
--
作者：
KALIN, NH;SHELTON, SE;BARKSDALE, CM
幼年恒河猴对与母亲分离的反应是发声显著增加，自主神经和垂体-肾上腺系统激活。使用恒河猴的母婴分离范式，我们重点研究了阿片系统在调节短暂的、自然发生的应激源的行为和神经内分泌后果中的作用。在第一个实验中，吗啡0.1 mg/kg显著减少了分离诱导的发声，但不影响活动水平。在第二个实验中，纳洛酮1.0 mg/kg增加了痛苦的发声，但较低剂量没有影响。在第三个实验中，我们用纳洛酮0.1 mg/kg阻断了吗啡0.1 mg/kg的作用，纳洛酮本身没有内在作用。这表明吗啡减少分离诱导的发声是由阿片受体介导的。最后的实验表明，分离引起的垂体-肾上腺激素的增加也可以被阿片激动剂和拮抗剂调节。这些发现与在非灵长类物种中的工作一致，并支持阿片受体特定地参与调节分离诱导的发声和灵长类动物的脑下-肾上腺激活的假说。
Infant rhesus monkeys respond to separation from their mothers with a dramatic increase in vocalizations and activation of autonomic and pituitary-adrenal systems. Using the mother-infant separation paradigm in rhesus monkeys, we focused on the role of opiate systems in modulating the behavioral and neuroendocrine consequences of a brief, naturally occurring stressor. In the first experiment, morphine 0.1 mg/kg significantly decreased separation-induced vocalizations without affecting activity levels. In the second experiment, naloxone 1.0 mg/kg increased distress vocalizations but lower doses had no effect. In the third experiment we blocked the effect of morphine 0.1 mg/kg with naloxone 0.1 mg/kg, a dose of naloxone that had no intrinsic effects of its own. This suggests that the reduction of separation-induced vocalizations by morphine is mediated by opiate receptors. The last experiment demonstrated that separation-induced increases in pituitary-adrenal hormones can also be modulated by opiate agonists and antagonists. These findings are consistent with work in non-primate species and support the hypothesis that opiate receptors are specifically involved in mediating separation-induced vocalizations and pituitary-adrenal activation in primates.