Targeting of type I interferon in systemic autoimmune diseases.
Targeting of type I interferon in systemic autoimmune diseases.
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DOI：
10.1016/j.trsl.2014.10.005
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发表时间：
2015-02
期刊：
影响因子：
--
通讯作者：
Kirou KA
中科院分区：
文献类型：
--
作者：
Crow MK;Olferiev M;Kirou KA
在许多系统性自身免疫性疾病患者中观察到I型干扰素（IFN-I）的血液水平增加和反映IFN-I诱导的基因转录物的广泛签名的表达，并且该模式在系统性红斑狼疮（SLE）中最为显著。持续产生IFN-α（在这些患者中测量到的最丰富的亚型）是狼疮免疫发病机制的重要特征，并且刺激了目前开发和测试直接阻断IFNI或其受体或靶向参与IFN-I诱导或应答的IFN-I途径组分的治疗剂的努力。本综述将描述来自慢性病毒感染动物模型的数据，与影响IFN-I通路的单基因突变相关的狼疮样综合征的例子，以及来自狼疮患者的纵向研究，以支持SLE中IFN-I通路治疗靶向的基本原理。然而，IFN-I调节的复杂性及其对免疫系统功能的影响的多样性表明，该途径作为有效和有效的治疗靶点的明确证明只能来自在全身性自身免疫疾病患者中测试的药物的临床试验，狼疮患者可能是最具信息性的。
Increased blood levels of type I interferon (IFN-I) and expression of a broad signature of gene transcripts that reflect induction by IFN-I are observed in many patients with systemic autoimmune diseases, and that pattern is most striking in systemic lupus erythematosus (SLE). Persistent production of IFN-α, the most abundant subtype measured in these patients, is an important feature of the immunopathogenesis of lupus and has stimulated current efforts to develop and test therapeutics that either block IFNI or its receptor directly or target components of the IFN-I pathway involved in induction of or response to IFN-I. This review will describe data from animal models of chronic viral infection, examples of lupus-like syndromes associated with single-gene mutations that impact the IFN-I pathway, and longitudinal studies from lupus patients to support the rationale for therapeutic targeting of the IFN-I pathway in SLE. However, the complexity of IFN-I regulation and the diversity of its effects on immune system function suggest that the definitive demonstration of that pathway as a valid and productive therapeutic target will only come from clinical trials of agents tested in patients with systemic autoimmune disease, with lupus patients likely to be the most informative.
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影响因子：
13.3
作者：
Chiche, Laurent;Jourde-Chiche, Noemie;Whalen, Elizabeth;Presnell, Scott;Gersuk, Vivian;Dang, Kristen;Anguiano, Esperanza;Quinn, Charlie;Burtey, Stephane;Berland, Yvon;Kaplanski, Gilles;Harle, Jean-Robert;Pascual, Virginia;Chaussabel, Damien
通讯作者：
Chaussabel, Damien
影响因子：
4.1
作者：
Francois-Newton, Veronique;Livingstone, Mark;Pellegrini, Sandra
通讯作者：
Pellegrini, Sandra
DOI：
10.4049/jimmunol.1201477
发表时间：
2012-12-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Baccala R;Gonzalez-Quintial R;Schreiber RD;Lawson BR;Kono DH;Theofilopoulos AN
通讯作者：
Theofilopoulos AN
DOI：
10.1084/jem.20021553
发表时间：
2003-03-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bennett L;Palucka AK;Arce E;Cantrell V;Borvak J;Banchereau J;Pascual V
通讯作者：
Pascual V
影响因子：
3.7
作者：
Hardy GA;Sieg S;Rodriguez B;Anthony D;Asaad R;Jiang W;Mudd J;Schacker T;Funderburg NT;Pilch-Cooper HA;Debernardo R;Rabin RL;Lederman MM;Harding CV
通讯作者：
Harding CV