Autophagy, a key mechanism of oncogenesis and resistance in leukemia
Autophagy, a key mechanism of oncogenesis and resistance in leukemia
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DOI：
10.1182/blood-2016-07-692707
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发表时间：
2017-02-02
期刊：
影响因子：
20.3
通讯作者：
Puissant, Alexandre
中科院分区：
文献类型：
--
作者：
Auberger, Patrick;Puissant, Alexandre
自噬是参与细胞内物质降解的溶酶体途径。它似乎是一种适应机制，对细胞在各种应激条件下的稳态至关重要。在过去的十年中，许多研究已经将自噬的改变与癌症的发生和进展、自身免疫性疾病、炎症性疾病、代谢性疾病和退行性疾病联系起来。本文综述了自噬对正常造血干细胞白血病转化的影响，并总结了其在白血病细胞化疗反应中的作用。
Autophagy is a lysosomal pathway involved in degradation of intracellular material. It appears as an adaptation mechanism that is essential for cellular homeostasis in response to various stress conditions. Over the past decade, many studies have linked alteration of autophagy with cancer initiation and progression, autoimmune, inflammatory, metabolic, and degenerative diseases. This review highlights recent findings on the impact of autophagy on leukemic transformation of normal hematopoietic stem cells and summarizes its role on leukemic cell response to chemotherapy.