Comparison of neutralizing and hemagglutination-inhibiting antibody responses to influenza A virus vaccination of human immunodeficiency virus-infected individuals
Comparison of neutralizing and hemagglutination-inhibiting antibody responses to influenza A virus vaccination of human immunodeficiency virus-infected individuals
复制标题
DOI：
10.1128/cdli.5.1.114-117.1998
复制
发表时间：
1998-01-01
期刊：
影响因子：
--
通讯作者：
De Jong, JC
中科院分区：
文献类型：
--
作者：
Benne, CA;Kroon, FP;De Jong, JC
采用中和酶免疫测定法（N-EIA）测定51名1型人类免疫缺陷病毒（HIV）感染者和10名健康非感染对照接种流感病毒后A/Taiwan/1/86（H1N1）和Beijing/353/89（H3 N2）病毒的中和血清抗体滴度。总体而言，N-EIA滴度与先前研究中在相同样品中观察到的血凝抑制（HAI）滴度相关性良好（F，P，Kroon，J. T，货车Dissel，J，C. de Jong和R.货车Furth，AIDS 8：469- 476，1994），N-EIA似乎比HAI试验更敏感，在每μ l大于或等于200个CD 4（+）细胞的HIV感染个体中，N-EIA滴度显著增加4倍或更高，平均N-EIA滴度更高。
A neutralization enzyme immunoassay (N-EIA) was used to determine the neutralizing serum antibody titers to influenza A/Taiwan/1/86 (H1N1) and Beijing/353/89 (H3N2) viruses after vaccination of 51 human immunodeficiency virus (HIV) type 1-infected individuals and 10 healthy noninfected controls against influenza virus infection. Overall, the N-EIA titers correlated well with the hemagglutination-inhibition (HAI) titers that were observed in the same samples in a previous study (F, P, Kroon, J. T, van Dissel, J, C. de Jong, and R. van Furth, AIDS 8:469-476,1994), The N-EIA appeared to be more sensitive than the HAI test, Significantly more fourfold or higher rises in N-EIA titer and higher mean N-EIA titers occurred in HIV-infected individuals with greater than or equal to 200 CD4(+) cells per mu l than in those with