Transmission of influenza A/H5N1 viruses in mammals.
Transmission of influenza A/H5N1 viruses in mammals.
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DOI:
10.1016/j.virusres.2013.07.017
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发表时间:
2013-12-05
期刊:
影响因子:
5
通讯作者:
Kawaoka Y
中科院分区:
文献类型:
--
作者:
Imai M;Herfst S;Sorrell EM;Schrauwen EJ;Linster M;De Graaf M;Fouchier RA;Kawaoka Y
Highly pathogenic avian H5N1 influenza A viruses occasionally infect humans and cause severe respiratory disease and fatalities. Currently, these viruses are not efficiently transmitted from person to person, although limited human-to-human transmission may have occurred. Nevertheless, further adaptation of avian H5N1 influenza A viruses to humans and/or reassortment with human influenza A viruses may result in aerosol transmissible viruses with pandemic potential. Although the full range of factors that modulate the transmission and replication of influenza A viruses in humans are not yet known, we are beginning to understand some of the molecular changes that may allow H5N1 influenza A viruses to transmit via aerosols or respiratory droplets among mammals. A better understanding of the biological basis and genetic determinants that confer transmissibility to H5N1 influenza A viruses in mammals is important to enhance our pandemic preparedness.
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通讯作者:
Kawaoka, Yoshihiro
DOI:
10.1126/science.1213362
发表时间:
2012-06-22
期刊:
Science (New York, N.Y.)
影响因子:
--
作者:
Herfst S;Schrauwen EJ;Linster M;Chutinimitkul S;de Wit E;Munster VJ;Sorrell EM;Bestebroer TM;Burke DF;Smith DJ;Rimmelzwaan GF;Osterhaus AD;Fouchier RA
通讯作者:
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