Transmission of influenza A/H5N1 viruses in mammals.

Transmission of influenza A/H5N1 viruses in mammals.
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DOI:
10.1016/j.virusres.2013.07.017
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发表时间:
2013-12-05
期刊:
影响因子:
5
通讯作者:
Kawaoka Y
Kawaoka Y
中科院分区:
医学3区
文献类型:
--
作者:
Imai M;Herfst S;Sorrell EM;Schrauwen EJ;Linster M;De Graaf M;Fouchier RA;Kawaoka Y

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高致病性H5N1禽流感病毒偶尔会感染人类,并导致严重的呼吸道疾病和死亡。目前,这些病毒没有有效地在人与人之间传播,尽管可能发生了有限的人与人之间的传播。然而,禽流感H5N1流感病毒进一步适应人类和/或与人类甲型流感病毒重新组合可能导致具有大流行潜力的气雾剂传播病毒。虽然调控甲型流感病毒在人类体内传播和复制的各种因素尚不清楚,但我们开始了解一些分子变化,这些变化可能允许H5N1甲型流感病毒通过气雾剂或呼吸道飞沫在哺乳动物中传播。更好地了解使H5N1甲型流感病毒在哺乳动物中传播的生物学基础和遗传决定因素,对于加强我们对大流行的防范非常重要。
Highly pathogenic avian H5N1 influenza A viruses occasionally infect humans and cause severe respiratory disease and fatalities. Currently, these viruses are not efficiently transmitted from person to person, although limited human-to-human transmission may have occurred. Nevertheless, further adaptation of avian H5N1 influenza A viruses to humans and/or reassortment with human influenza A viruses may result in aerosol transmissible viruses with pandemic potential. Although the full range of factors that modulate the transmission and replication of influenza A viruses in humans are not yet known, we are beginning to understand some of the molecular changes that may allow H5N1 influenza A viruses to transmit via aerosols or respiratory droplets among mammals. A better understanding of the biological basis and genetic determinants that confer transmissibility to H5N1 influenza A viruses in mammals is important to enhance our pandemic preparedness.
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