Diminished corneal angiogenesis in gelatinase A-deficient mice
Diminished corneal angiogenesis in gelatinase A-deficient mice
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DOI：
10.1016/s0014-5793(01)02897-6
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发表时间：
2001-11-16
期刊：
影响因子：
3.5
通讯作者：
Azar, DT
中科院分区：
文献类型：
--
作者：
Kato, T;Kure, T;Azar, DT
本研究的目的是确定明胶酶A在血管生成中的作用。我们在明胶酶A缺陷小鼠及其年龄匹配的野生型同窝仔中进行了角膜微囊测定。明胶酶A缺陷小鼠的角膜新生血管面积（0.15 +/- 0.14 mm（2））显著小于野生型同窝小鼠（0.53 +/- 0.35 mm（2）- P < 0.01）。同样，主动脉环测定显示，与野生型同窝小鼠相比，明胶酶A缺陷小鼠的内皮生长显著减少（0.26 ± 0.14 mm（2））（0.44 ± 0.06 mm（2）; P < 0.05）。这些结果表明，明胶酶A可能在角膜血管生成的调节中发挥重要作用。(C)2001年由Elsevier Science B. V.代表欧洲生物化学学会联合会出版。
The goal of the present study was to define the role of gelatinase A in angiogenesis. We performed corneal micropocket assays in gelatinase A-deficient mice and their age-matched wildtype littermates. The corneal neovascular area in gelatinase A-deficient mice (0.15 +/- 0.14 mm(2)) was significantly less than that of wild-type littermates; (0.53 +/- 0.35 mm(2) - P < 0.01). Similarly, aortic ring assays showed significant reduction of endothelial outgrowth in gelatinase A-deficient mice (0.26 +/- 0.14 mm(2)) as compared to wild-type littermates (0.44 +/- 0.06 mm(2); P < 0.05). These results suggest that gelatinase A may play an important role in the regulation of corneal angiogenesis. (C) 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.