Development of the X-linked tetrameric microsatellite markers HumDXS6803 and HumDXS9895 for forensic purpose
Development of the X-linked tetrameric microsatellite markers HumDXS6803 and HumDXS9895 for forensic purpose
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DOI：
10.1016/s0379-0738(03)00077-x
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发表时间：
2003-05-05
影响因子：
2.2
通讯作者：
Yang, RZ
中科院分区：
文献类型：
--
作者：
Huang, DX;Yang, QG;Yang, RZ
本文介绍了 X 连锁 DXS6803 和 DXS9895 短串联重复序列 (STR) 的序列和群体遗传数据。四核苷酸重复多态性DXS6803（也称为CHLC.GATA45H11）和DXS9895（也称为CHLC.GATA124B04）分别位于Xq12-Xq21.33和Xpter-Xp22.2区域。在亲属关系测试中，DXS6803和DXS9895适合同时使用。通过分析中国汉族人群中 182 名无亲缘关系的女性和 110 名男性，获得了群体遗传数据。在该群体中，DXS6803 和 DXS9895 均表现出七个明显可区分的等位基因，长度分别为 109 bp 至 128 bp 和 139 bp 至 163 bp。 Hardy-Weinberg 平衡 (HWE) 测试显示这两个基因座没有显着偏差。 DXS6803 的多态性信息含量 (PIC)、观察到的杂合性 (H-obs) 和女孩三重奏 (PEtrio) 和二重奏 (PEduo) 亲子鉴定的排除力分别为 0.67、0.687、0.673 和 0.530，DXS6803 为 0.69、0.736、0.688 和 0.547。分别是DXS9895。对这两个基因座的 78 个家族研究证实了 X 连锁共显性遗传，但未发现突变。 (C) 2003 Elsevier Science Ireland Ltd. 保留所有权利。
This paper presents sequence and population genetic data of the X-linked DXS6803 and DXS9895 short tandem repeat (STR). The tetranucleotide repeat polymorphism DXS6803 (also known as CHLC.GATA45H11) and DXS9895 (also known as CHLC.GATA124B04) are located at the Xq12-Xq21.33 and Xpter-Xp22.2 region, respectively. In kinship testing, DXS6803 and DXS9895 are suitable for concomitant use. Population genetic data were obtained by analyzing 182 unrelated females and 110 males from Chinese Han population. In this population, both DXS6803 and DXS9895 exhibited seven clearly distinguishable alleles ranging from 109 bp to 128 bp and 139 bp to 163 bp in length, respectively. Testing for Hardy-Weinberg equilibrium (HWE) showed no significant deviation for these two loci. The polymorphism information content (PIC), observed heterozygosity (H-obs) and power of exclusion for parentage testing of a girl for trios (PEtrio) and duos (PEduo) were 0.67, 0.687, 0.673 and 0.530 for DXS6803, and 0.69, 0.736,0.688 and 0.547 for DXS9895, respectively. Seventy-eight families studies of these two loci confirmed X-linked codominant inheritance and mutations were not found. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.