Regulation of cardiovascular calcification by lipids and lipoproteins.
Regulation of cardiovascular calcification by lipids and lipoproteins.
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DOI：
10.1097/mol.0000000000000844
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发表时间：
2022-10-01
影响因子：
4.4
通讯作者：
Demer, Linda L.
中科院分区：
文献类型：
--
作者：
Hsu, Jeffrey J.;Tintut, Yin;Demer, Linda L.
长期以来，脂类和脂蛋白一直被认为是导致动脉粥样硬化和心血管钙化的因素。最近工作的一个主题是对脂蛋白(A)[Lp(A)]的研究，脂蛋白(A)是一种类似于低密度脂蛋白-胆固醇的脂蛋白颗粒，携带着长长的载脂蛋白尾巴和大多数循环中的氧化磷脂。体外研究表明，Lp(A)刺激成骨细胞分化和血管平滑肌细胞矿化，而Lp(A)与冠状动脉钙化的相关性仍有不同的结果，这可能是由于相关性分析所选择的Lp(A)的阈值水平存在很大差异。心血管钙化领域的另一个新兴领域是病理性内皮细胞向间充质细胞转变(EndMT)，即内皮细胞向多能间充质细胞转化的过程，其中一些细胞分化为骨软骨细胞并矿化。脂类和脂蛋白对EndMT的影响表明，它们通过多种机制调节心血管钙化。钙化性血管病变的成像也出现了新的趋势，包括：用于量化斑块特征的血管内光学相干断层扫描，使用放射性标记的NaF示踪剂的正电子发射断层扫描，以及用于检测冠状动脉斑块易损性的CT或MRI。最近在这一领域的工作包括Lp(A)、EndMT和新的成像技术的研究。
Lipids and lipoproteins have long been known to contribute to atherosclerosis and cardiovascular calcification. One theme of recent work is the study of lipoprotein (a) [Lp(a)], a lipoprotein particle similar to LDL-cholesterol that carries a long apoprotein tail and most of the circulating oxidized phospholipids. In vitro studies show that Lp(a) stimulates osteoblastic differentiation and mineralization of vascular smooth muscle cells, while the association of Lp(a) with coronary artery calcification continues to have varying results, possibly due to the widely varying threshold levels of Lp(a) chosen for association analyses. Another emerging area in the field cardiovascular calcification is pathological endothelial to mesenchymal transition (EndMT), the process whereby endothelial cells transition into multipotent mesenchymal cells, some of which differentiate into osteo-chondrogenic cells and mineralize. The effects of lipids and lipoproteins on EndMT suggest they modulate cardiovascular calcification through multiple mechanisms. There are also emerging trends in imaging of calcific vasculopathy, including: intravascular optical coherence tomography for quantifying plaque characteristics, positron emission tomography with a radiolabeled NaF tracer, with either CT or MRI to detect coronary plaque vulnerability. Recent work in this field includes studies of Lp(a), EndMT, and new imaging techniques.
影响因子：
2.3
作者：
Mao, Yongzhong;Jiang, Ling
通讯作者：
Jiang, Ling