Thinning faster? Age-related cortical thickness differences in adults with autism spectrum disorder
Thinning faster? Age-related cortical thickness differences in adults with autism spectrum disorder
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DOI：
10.1016/j.rasd.2019.03.005
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发表时间：
2019-08-01
影响因子：
2.5
通讯作者：
Riecken, Cory
中科院分区：
文献类型：
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作者：
Braden, B. Blair;Riecken, Cory
背景：在过去的30年里，自闭症谱系障碍（ASD）的诊断有所增加，从而确定了一大批患有ASD的老年人。目前，与神经典型（NT）人群相比，关于衰老将如何影响这些个体的神经解剖学知之甚少。由于ASD相关的皮质病理和年龄相关的皮质变薄的解剖重叠，两者都遵循前到后的严重程度梯度，我们假设ASD成人将比NT成人表现出更大的年龄相关皮质变薄。方法：我们使用来自多站点自闭症脑成像数据交换I（依从I； n = 282）和我们自己的有或无ASD的中至老年人队列（n = 47）的可用数据分析皮质测量结果，这些数据主要来自依从II （n = 35）。我们比较了右撇子ASD成人（n = 157）和类似的NT成人（n = 172）的皮质测量与年龄的相关性，控制了智商和部位。参与者年龄为18-64岁（平均29.8岁，中位数26岁）。结果：我们发现年龄与左额叶（包部）、颞叶（下回、中回、颞上沟库和内嗅皮质）、顶叶（下回）和侧枕叶皮质厚度的关系在诊断组之间存在显著差异。在所有区域中，ASD成人的年龄与皮质厚度之间的负相关大于NT成人。结论：正如假设的那样，与NT成人相比，ASD成人表现出与年龄相关的皮质变薄加剧。这些差异在左颞叶最大、最广泛。未来的纵向研究是有必要的，以调查大脑年龄轨迹的差异是否会转化为老年ASD患者独特的行为需求。
Background: Over the course of the last 30 years, autism spectrum disorder (ASD) diagnoses have increased, thus identifying a large group of aging individuals with ASD. Currently, little is known regarding how aging will affect these individual's neuroanatomy, compared to the neurotypical (NT) population. Because of the anatomical overlap of ASD-related cortical pathology and age related cortical thinning, both following an anterior-to-posterior severity gradient, we hypothesize adults with ASD will show larger age-related cortical thinning than NT adults.Methods: We analyzed cortical measurements using available data from the multi-site Autism Brain Imaging Data Exchange I (ABIDE I; n = 282) and our own cohort of middle-age to older adults with and without ASD (n = 47) mostly available in ABIDE II (n = 35). We compared correlations between cortical measures and age in right-handed adults with ASD (n = 157) and similar NT adults (n = 172), controlling for IQ and site. Participants were 18-64 years of age (mean = 29.8 years; median = 26 years).Results: We found significant differences between diagnosis groups in the relationship between age and cortical thickness for areas of left frontal lobe (pars opercularis), temporal lobe (inferior gyrus, middle gyrus, banks of the superior temporal sulcus, and entorhinal cortex), parietal lobe (inferior gyrus), and lateral occipital lobe. For all areas, adults with ASD showed a greater negative correlation between age and cortical thickness than NT adults.Conclusion: As hypothesized, adults with ASD demonstrated exacerbated age-related cortical thinning, compared to NT adults. These differences were the largest and most extensive in the left temporal lobe. Future longitudinal work is warranted to investigate whether differences in brain age trajectories will translate to unique behavioral needs in older adults with ASD.