Cholangiocarcinoma: lessons from Thailand
Cholangiocarcinoma: lessons from Thailand
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DOI：
10.1097/mog.0b013e3282fbf9b3
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发表时间：
2008-05-01
影响因子：
2.5
通讯作者：
Pairojkul, Chawalit
中科院分区：
文献类型：
--
作者：
Sripa, Banchob;Pairojkul, Chawalit
综述目的介绍泰国肝吸虫相关胆管癌的发病背景，重点介绍肝吸虫相关胆管癌的最新流行病学资料和发病机制。最近的发现：在泰国，越来越系统的肿瘤登记发现了新的高发地区，不仅局限于东北部，而且还局限于泰国北部的一些省份。肝吸虫、蛇胸菌和胆管癌之间的联系，特别是在细胞和分子发病机制方面，进一步阐明。泰国仍然是世界上胆管癌发病率最高的国家。肝吸虫诱导慢性炎症，导致受感染的胆道上皮DNA氧化损伤和恶性转化。迫切需要根除吸虫并确定高危人群。
Purpose of reviewTo present the background of liver fluke-associated cholangiocarcinoma in Thailand focusing on recent epidemiological data and pathogenesis of this bile duct cancer.Recent findingsMore systematic tumor registration in Thailand nowadays uncovers new high-incidence areas that are confined to not only the northeastern part but also some provinces in northern Thailand. The link between the liver fluke, Opisthorchis viverrini, and cholangiocarcinoma, particularly in terms of cellular and molecular pathogenesis, is further elucidated.SummaryThailand is still the country with the highest incidence of cholangiocarcinoma in the world. Liver fluke induces chronic inflammation leading to oxidative DNA damage of the infected biliary epithelium and malignant transformation. Eradication of the fluke and identification of high-risk populations are urgently needed.