Gracilioethers A-C, Antimalarial Metabolites from the Marine Sponge Agelas gracilis
Gracilioethers A-C, Antimalarial Metabolites from the Marine Sponge Agelas gracilis
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DOI：
10.1021/jo900380f
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发表时间：
2009-06-05
影响因子：
3.6
通讯作者：
Fusetani, Nobuhiro
中科院分区：
文献类型：
--
作者：
Ueoka, Reiko;Nakao, Yoichi;Fusetani, Nobuhiro
从海绵Agelas gracilis中分离得到三个新的抗原动物化合物，即gracilioethers A-C（1-3）。根据光谱和化学方法鉴定了它们的结构。Gracilioethers A-C对恶性疟原虫显示抗疟活性，IC 50值为0.5-10 μ g/mL，而Gracilioethers B（2）也显示抗利什曼原虫活性。
Three new antiprotozoan compounds, gracilioethers A-C (1-3), have been isolated from the marine sponge Agelas gracilis. Their structures were elucidated on the basis of spectroscopic and chemical methods. Gracilioethers A-C showed antimalarial activity against Plasmodium falciparum with IC50 values of 0.5-10 mu g/mL, whereas gracilioether B (2) also showed antileishmanial activity.