Design, Synthesis, Crystal Structure and Antitumor Activity of A New Ethyl 3-(quinazolin-4-ylamino)-1H-pyrrole-2-carboxylate Derivative
Design, Synthesis, Crystal Structure and Antitumor Activity of A New Ethyl 3-(quinazolin-4-ylamino)-1H-pyrrole-2-carboxylate Derivative
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DOI：
10.2174/157018009789108240
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发表时间：
2009-10-01
影响因子：
1
通讯作者：
Ji, Min
中科院分区：
文献类型：
--
作者：
Zheng, Youguang;Wu, Xiaoqing;Ji, Min
设计合成了一种新的乙基3-(quinazolin-4-ylamino)-1H-pyrrole-2-carboxylate类抗肿瘤药物，其结构经核磁共振氢谱H-1、核磁共振碳谱C-13、红外光谱、质谱和元素分析确证。在体外对人胰腺癌Miacapa2、胰腺癌Panc1、前列腺癌DU145和前列腺癌PC3细胞进行了抗肿瘤活性测试，并用X射线晶体分析对目标化合物的晶体结构进行了表征。
A new ethyl 3-(quinazolin-4-ylamino)-1H-pyrrole-2-carboxylate derivative has been designed and synthesized as antitumor agent, which was identified by (HNMR)-H-1, (CNMR)-C-13, IR, MS and EA. The antitumor activity of the new compound was tested against human pancreatic cancer Miacapa2, pancreatic cancer Panc1, prostate cancer DU145 and prostate cancer PC3 cells in vitro, and the target compound crystal structure has been characterized by x-ray crystal analysis.