Sodium Hypochlorite/Salicylic Acid Shampoo for Treatment of Canine Staphylococcal Pyoderma
Sodium Hypochlorite/Salicylic Acid Shampoo for Treatment of Canine Staphylococcal Pyoderma
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DOI：
10.5326/jaaha-ms-6628
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发表时间：
2019-05-01
影响因子：
1.3
通讯作者：
Irwin, Katherine
中科院分区：
文献类型：
--
作者：
Fadok, Valerie A.;Irwin, Katherine
耐甲氧西林假中间葡萄球菌的出现增加了局部治疗犬脓癣的兴趣。通常建议先用洗必泰洗发，然后用稀释的漂白剂冲洗，但家用漂白剂会使皮肤干燥，使用起来不舒服。用次氯酸钠和水杨酸配制的洗发剂作为与S. pseudintermedius，包括耐甲氧西林菌株。根据耐甲氧西林葡萄球菌培养阳性或既往脓毒症对抗生素无反应，招募客户拥有的犬。这项前瞻性、开放标签的试点研究评估了洗发水每周使用三次，持续4周的疗效。通过细胞学、临床检查和主人评估，在基线以及第2周和第4周对犬进行评价。还获得了数字图像。基线细菌计数、临床评估和主人评分在2周和4周时显著改善。完成研究的客户报告说，白色和浅色涂层具有出色的起泡和分散性，气味减少，增亮。在研究期间，没有主人报告皮肤干燥或其他不良事件。我们的结论是，这种洗发水含有次氯酸钠的车辆，避免皮肤干燥是一种有效的治疗犬化脓。
The emergence of methicillin-resistant Staphylococcus pseudintermedius has increased the interest in topical therapy for treating canine pyoderma. Shampooing with chlorhexidine followed by dilute bleach rinses are often recommended, but household bleach can dry the skin and is unpleasant to use. A shampoo formulated with sodium hypochlorite and salicylic acid was evaluated as sole therapy for dogs with superficial pyoderma associated with S. pseudintermedius, including methicillin-resistant strains. Client-owned dogs were recruited based on positive culture for methicillin-resistant staphylococci or prior failure of pyoderma to respond to antibiotics. This prospective, open-label pilot study assessed the efficacy of the shampoo when used three times weekly for 4 wk. Dogs were evaluated at baseline and at 2 and 4 wk by cytology, clinical examination, and owner assessment. Digital images were also obtained. Baseline bacterial counts, clinical assessments and owner scores were significantly improved at 2 and 4 wk. Clients completing the study reported excellent lathering and dispersion, reduction in odor, and brightening of white and light coats. No owners reported skin dryness or other adverse events during the study. We conclude that this shampoo containing sodium hypochlorite in a vehicle that avoids skin drying is an effective treatment for canine pyoderma.