Roles of ubiquitinylation in proteolysis and cellular regulation.
Roles of ubiquitinylation in proteolysis and cellular regulation.
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泛素化在蛋白水解和细胞调节中的作用。
DOI：
10.1146/annurev.nu.15.070195.001113
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发表时间：
1995
影响因子：
8.9
通讯作者：
K. Wilkinson
中科院分区：
文献类型：
--
作者：
K. Wilkinson
大多数真核生物通过增加细胞内蛋白质水解的速率来响应饥饿、营养剥夺和/或应激。释放的氨基酸可以再利用于重要蛋白质的合成，或直接用于能量的生产。这种增强的蛋白水解也是修复由于环境损伤如热休克、自由基、病毒感染或突变引起的细胞损伤所必需的。最后，细胞内蛋白水解在确定各种调节蛋白的稳态水平中是重要的，特别是那些调节细胞周期的蛋白。泛素依赖的蛋白水解系统参与所有这些功能。尽管它的细胞质定位，该系统是选择性的，仅作用于有限的一组基板。本文综述了这种选择性的机制和泛素依赖的蛋白水解的潜在作用。
Most eukaryotic organisms respond to starvation, nutrient deprivation, and/or stress by increasing the rates of intracellular proteolysis. The amino acids released may be reutilized for synthesis of important proteins, or directly for the production of energy. This enhanced proteolysis is also required for repair of cellular damage due to environmental insults such as heat shock, free radicals, viral infection, or mutation. Finally, intracellular proteolysis is important in determining the steady-state levels of a wide variety of regulatory proteins, particularly those regulating the cell cycle. The ubiquitin-dependent proteolytic system participates in all of these functions. In spite of its cytoplasmic localization, this system is selective and acts only on a limited set of substrates. This review discusses the mechanisms of this selectivity and the potential roles of ubiquitin-dependent proteolysis.
影响因子：
3.9
作者：
D. J. Tierney;A. Haas;D. Koop
通讯作者：
D. J. Tierney;A. Haas;D. Koop
影响因子：
56.9
作者：
BACHMAIR, A;FINLEY, D;VARSHAVSKY, A
通讯作者：
VARSHAVSKY, A