Robotic microscopy for everyone: the OpenFlexure Microscope
Robotic microscopy for everyone: the OpenFlexure Microscope
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适合所有人的机器人显微镜：OpenFlexure 显微镜
DOI：
10.1101/861856
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Collins J
中科院分区：
文献类型：
--
作者：
Collins J
光学显微镜是临床疾病检测和科学分析的重要工具。然而，在世界上大部分地区，高性能显微镜的使用受到设备前期成本和维护成本的限制。在这里，我们展示了一个开源的，3d打印的，全自动的实验室显微镜，具有电动样品定位和焦点控制。显微镜是高度可定制的，有许多选择，包括反和外伸照明，偏振对比成像，和外伸荧光成像。OpenFlexure显微镜的设计使本地人员能够进行小批量生产和维护，大大增加了可访问性。我们已经在坦桑尼亚和肯尼亚生产了100多台显微镜，用于教育、科学和临床应用，这表明当地制造可以成为国际供应链的可行替代方案，而国际供应链往往成本高昂、速度缓慢且不可靠。
Optical microscopes are an essential tool for both the detection of disease in clinics, and for scientific analysis. However, in much of the world access to high-performance microscopy is limited by both the upfront cost and maintenance cost of the equipment. Here we present an open-source, 3D-printed, and fully-automated laboratory microscope, with motorised sample positioning and focus control. The microscope is highly customisable, with a number of options readily available including trans- and epi- illumination, polarisation contrast imaging, and epi-florescence imaging. The OpenFlexure microscope has been designed to enable low-volume manufacturing and maintenance by local personnel, vastly increasing accessibility. We have produced over 100 microscopes in Tanzania and Kenya for educational, scientific, and clinical applications, demonstrating that local manufacturing can be a viable alternative to international supply chains that can often be costly, slow, and unreliable.