Inactivation and partition of human T‐cell lymphotrophic virus, type III, during ethanol fractionation of plasma
Inactivation and partition of human T‐cell lymphotrophic virus, type III, during ethanol fractionation of plasma
复制标题
血浆乙醇分级过程中人 T 细胞淋巴病毒 III 型的灭活和分离
作者：
M. Wells;A. Wittek;J. Epstein;C. Marcus;S. Daniel;D. Tankersley;M. S. Preston;G. Quinnan,
文摘：出于对注射用免疫球蛋白安全性的担忧，我们研究了人血浆乙醇分级对人淋巴组织病毒III型(HTLV-III)的影响，在不同分级的产物中加入HTLV-III。灭活和去除试验表明，制备注射用免疫球蛋白的沉淀II的血浆部分中残留的活病毒与起始血浆中的活病毒的比率约为1×10-15。关于免疫球蛋白的潜在安全性，结果令人放心。
Abstract: Because of concern about the safety of immune globulins prepared for injection, we studied the effects of ethanol fractionation of human plasma on human lymphotropic virus, type III, (HTLV‐III) by spiking the products of various fractionation stops with HTLV‐III. Tests of inactivation and removal indicated that the ratio of residual live virus in plasma fractions/live virus in starting plasma was about 1 × 10‐15 for precipitate II from which immune globulin for injection is manufactured. The results are reassuring regarding the potential safety of immune globulin.