Thomas sydenham (1624-1689), on gout: 1717.
Thomas sydenham (1624-1689), on gout: 1717.
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托马斯·西德纳姆（Thomas sydenham，1624-1689），论痛风：1717 年。
DOI：
10.1097/01.rhu.0000135772.83956.74
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
B. Dorwart
中科院分区：
文献类型：
--
作者：
B. Dorwart
“他上床睡觉，睡得很好，但凌晨两点左右，他被疼痛吵醒，抓住他的大脚趾、脚后跟、小腿或脚踝；这种疼痛就像脱臼的骨头，感觉……水几乎冷，倒在受影响部位的膜上……；目前颤抖和颤抖，随后是发烧的性格；疼痛开始是轻微的，但逐渐加剧……每小时，直到到了晚上，它就达到了高度……跗骨和跖骨……它抓住了……有时像狗咬，有时像重物；此外，受影响的部位有如此迅速而剧烈的疼痛，以至于它无法承受衣服的重量，也无法在床上艰难行走；夜晚……在疼痛中度过……也通过……不停地左右转动，以及它的不断变化。总是伴随着痉挛的整个身体的翻腾……也比不上受折磨的肢体的持续的烦躁和疼痛：有一千种徒劳的努力用来缓解疼痛，……然而，直到凌晨两点或三点，也就是说，（在第一次发作时花费了一夜和一天的时间）病人突然缓解了，因为那里的原因。是腐臭物的一点消化……现在呼吸出汗，他睡着了……；当他醒来时，他发现疼痛大大减轻，受影响的部位又肿了；因为之前只有……可见的静脉肿胀与受影响的部位混合在一起，第二天，也许两三天后，如果容易产生痛风的物质大量，受影响的部位也会疼痛，到晚上也会很剧烈，但是到了公鸡打鸣的时候，情况就会有所缓解。”一旦疼痛停止，“导致身体虚弱的虚弱很快就会消失，力量和完美的健康状况会得到完美恢复，就好像从来没有出过问题一样……”对于那些“很少患痛风的人”来说，“通常在十四天内恢复到以前的健康状态，而对于那些经常受到痛风影响的人则在两个月内”。
“He goes to bed and sleeps well, but about 2 a sic clock in the morning, is waked by the pain, seizing either his great toe, the heel, the calf of the leg or the ancle sic; this pain is like that of dislocated bones, with the sense... of water almost cold, poured upon the membranes of the parts affected...; presently shivering and shaking follow with a feverish disposition; the pain is first gentle, but increases by degrees... and that hourly, till towards night it comes to its height... Bones of the tarsus and metatarsus... it seizes,... sometimes like the gnawing of a dog, and sometimes a weight; moreover, the part affected has such a quick and exquisite pain, that it is not able to bear the weight of the cloaths sic upon it nor hard walking in the bed chamber; and the night is... passed over in pain... also by... the restless turning of the part hither and thither, and the continual change of its place. Nor is the tossing of the whole body, which always accompanies the fit..., less than the continual agitation and pain of the tormented member: there are a thousand fruitless endeavors used to ease the pain,... yet there is no ease to be had, till 2 or 3 a-clock sic in the morning, viz.,(a night and a day being spent in the first approach of the fit) at which time the sick has suddenly ease sic, by reason there is a little digestion of the peccant matter.... And now being in a breathing sweat, he falls asleep...; when he wakes he finds the pain much abated, and the part affected swell’d sic afresh; for before there was only... visible a swelling of the veins intermixed with the affected members. The next day, and perhaps 2 or 3 after, if the matter apt to generate the gout is copious, the part affected will be in pain, which will be violent too towards evening, but it will be eased about the time of the cockscrowing;” once it has left off aching,“the weakness which rendered it infirm will presently vanish, strength and perfect health being so perfectly restored, as if it had never been out of order....” In those “whom the gout has rarely visited,” a return to their former health “comes to pass often in fourteen days, and in those that have been often affected by it in 2 months.”