Low density lipoprotein particle size decreases during normal pregnancy in association with triglyceride increases
Low density lipoprotein particle size decreases during normal pregnancy in association with triglyceride increases
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DOI：
10.1016/s1071-5576(98)00022-7
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发表时间：
1998-09-01
期刊：
影响因子：
--
通讯作者：
Roberts, JM
中科院分区：
文献类型：
--
作者：
Hubel, CA;Shakir, Y;Roberts, JM
目的：描述低密度脂蛋白（LDL）峰值粒径（主要LDL亚类的直径）的变化与血清甘油三酯浓度的变化在连续阶段的正常妊娠和postparty.METHODS：非空腹静脉血纵向期间和之后，从10个非吸烟的妇女无代谢紊乱的历史，无并发症的妊娠。用非变性聚丙烯酰胺凝胶电泳法测定血浆LDL直径。测定血清总胆固醇、甘油三酯、载脂蛋白B、载脂蛋白A-I和LDL胆固醇浓度。通过单因素重复测量方差分析和配对多重比较Student-Newman-Keuls检验来分析Gestival变化。Pearson相关系数计算血脂和LDL diameter.Results：低密度脂蛋白直径进行性下降，随着妊娠的推进，明显的16-20周相对于5-12周。10例中7例为B亚型（直径小于255埃或更大）与血清甘油三酯浓度（r = -.61，P < .0001），载脂蛋白B（r = -.66，P < .0001），胆固醇（r = - .53，P < .001），LDL胆固醇（r = -.45，P < .005），apoA-I（r = -.39，P < .02）。结论：在大多数病例中，甘油三酯升高伴随着LDL直径的进行性降低。这些变化在产后发生逆转，因此是短暂的。小而致密的LDL颗粒具有许多能够改变血管功能的特性。然而，妊娠期低密度脂蛋白含量降低对母体和胎儿代谢的影响尚不清楚。版权所有（C）1998由妇科调查协会。
OBJECTIVE: To characterize the changes in low-density lipoprotein (LDL) peak particle diameter (diameter of the predominant LDL subclass) in relation to changes in serum triglyceride concentration during successive stages of normal gestation and postpartum.METHODS: Nonfasting venous blood was obtained longitudinally during and after uncomplicated primiparous pregnancy from 10 nonsmoking women with no history of metabolic disorders. Plasma LDL diameter was determined by nondenaturing polyacrylamide gel electrophoresis. Serum concentrations of total cholesterol, triglyceride, apolipoprotein B, apolipoprotein A-I, and LDL-cholesterol were measured. Gestational changes were analyzed by one-way repeated-measures analysis of variance and the paired multiple comparison Student-Newman-Keuls test. Pearson coefficients were computed for correlation of serum lipids and LDL diameter.Results: Low-density lipoprotein diameter decreased progressively with advancing gestation, evident by 16-20 weeks relative to 5-12 weeks. Seven of 10 cases were subclass pattern B (diameter less than 255 Angstrom or more) by 6-12 weeks with concentrations of serum triglyceride (r = -.61, P < .0001), apo B (r = -.66, P < .0001), cholesterol (r = - .53, P < .001), LDL cholesterol (r = -.45, P < .005), and apo A-I (r = -.39, P < .02).CONCLUSION: Gestational triglyceride increases are accompanied by progressive decreases in LDL diameter in a majority of cases. These changes undergo reversal postpartum and therefore are transient. Small, dense LDL particles have a number of properties capable of altering vascular function. However, the consequences of the gestational LDL size decrease for maternal and fetal metabolism remain unknown. Copyright (C) 1998 by the Society for Gynecologic Investigation.