The Mouse Phenome Project
The Mouse Phenome Project
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DOI：
10.1007/s10709-004-1438-4
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发表时间：
2004-09-01
期刊：
影响因子：
1.5
通讯作者：
Grubb, SC
中科院分区：
文献类型：
--
作者：
Bogue, MA;Grubb, SC
实验室小鼠是许多生物学和医学研究的首选生物体。可靠的表型数据对于充分利用人类和小鼠基因组测序工作中出现的基因型信息至关重要。组织了小鼠表型组项目，以帮助完成这一任务，方法是收集常用和遗传多样性近交系小鼠品系的基线表型数据，并通过网络数据库公开提供这一信息。正在开发小鼠表型数据库（MPD）来管理这些数据，并为研究人员提供探索原始表型数据和比较总结分析的工具。MPD用作详细方案和原始数据的存储库。这一资源使研究人员能够确定合适的菌株，用于（1）生理测试，（2）药物发现，（3）毒理学研究，（4）诱变，（5）模拟人类疾病，（6）QTL分析和新基因的鉴定，以及（7）揭示环境对基因型的影响。
The laboratory mouse is the organism of choice for many studies in biology and medicine. Reliable phenotypic data are essential for the full utility of genotypic information emerging from efforts to sequence human and mouse genomes. The Mouse Phenome Project has been organized to help accomplish this task by establishing a collection of baseline phenotypic data on commonly used and genetically diverse inbred mouse strains and making this information publicly available through a web-accessible database. The Mouse Phenome Database (MPD) is being developed to manage these data and to provide researchers with tools for exploring both raw phenotypic data and comparative summary analyses. The MPD serves as a repository for detailed protocols and raw data. This resource enables investigators to identify appropriate strains for ( 1) physiological testing, ( 2) drug discovery, (3) toxicology studies, ( 4) mutagenesis, ( 5) modeling human diseases, ( 6) QTL analyses and identification of new genes and ( 7) unraveling the influence of environment on genotype.