Technetium Tc 99m rapidly crosses the ovine placenta and intramembranous pathway
Technetium Tc 99m rapidly crosses the ovine placenta and intramembranous pathway
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DOI：
10.1016/s0002-9378(96)70106-0
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发表时间：
1996-12-01
影响因子：
9.8
通讯作者：
Brace, RA
中科院分区：
文献类型：
--
作者：
Gilbert, WM;Newman, PS;Brace, RA
目的：本研究探讨了运动的可溶性离子锝99米通过羊胎盘和intramembranous pathway.Study Design：19胎羊在131 +/- 1（SE）天的妊娠进行了研究。在1小时的对照期后，将锝99 m注入胎儿静脉（n = 7）、羊膜腔（n = 5）或母体静脉（n = 5）。在对照期间和注射后8小时内采集母体和胎儿血液、胎儿尿液、羊水和尿囊液。在整个实验过程中，胎儿尿液从外部排出。在5只动物中，胎儿用空气栓塞法处死后，经羊膜腔内注射Tc 99 m，并按上述方法取样.结果：胎儿内注射Tc 99 m迅速穿过胎盘，进入羊膜腔，并在羊膜腔内浓缩.脑内注射Tc 99 m迅速进入胎儿循环。母体注射的Tc 99 m迅速穿过胎盘进入胎儿，提示胎盘交换的半衰期为
OBJECTIVE: This study examined the movement of the soluble ion technetium Tc 99m across the ovine placenta and intramembranous pathway.STUDY DESIGN: Nineteen fetal sheep at 131 +/- 1 (SE) days' gestation were studied. After a 1-hour control period technetium Tc 99m was injected into either a fetal vein (n = 7), the amniotic cavity (n = 5), or a maternal vein (n = 5). Maternal and fetal blood, fetal urine, and amniotic and allantoic fluid were sampled during the control period and for 8 hours after the injection. Fetal urine was drained externally throughout the experiment. In five animals technetium Tc 99m was injected intraamniotically after the fetus was killed with air emboli and sampled as described.RESULTS: Intrafetally injected technetium Tc 99m rapidly crossed the placenta; then it entered and was concentrated in the amniotic cavity. Intraamniotically injected technetium Tc 99m rapidly entered into the fetal circulation. The maternally injected technetium Tc 99m rapidly crossed the placenta into the fetus, suggesting a half-time for placental exchange of