HPV in anal squamous cell carcinoma and anal intraepithelial neoplasia (AIN)
HPV in anal squamous cell carcinoma and anal intraepithelial neoplasia (AIN)
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肛门鳞状细胞癌和肛门上皮内瘤变 (AIN) 中的 HPV
DOI：
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发表时间：
2006
影响因子：
2.8
通讯作者：
D. Decker
中科院分区：
文献类型：
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作者：
A. Várnai;M. Bollmann;H. Griefingholt;N. Speich;C. Schmitt;R. Bollmann;D. Decker
背景和目的肛门鳞状细胞癌大多数病例是由人乳头状瘤病毒（HPV）诱导的，是肛门上皮内瘤变（AIN）的结果。本研究的目的是检查HPV引起的肛缘变化的常规诊断方法，以及这种检测的结果，特别是考虑到AIN的更敏感诊断。结果临床correlated.MethodsThe研究包括活检样本87例已被诊断为以下疾病模式：47浸润性肛门癌，33 AIN的不同严重程度和7个尖锐湿疣病变。在这些病例中，有52例临床怀疑为肿瘤。回顾性检查所有活检标本的HPV感染的显微镜指征。结果47例肛门癌中38例（80.9%）可检出HPV DNA，其中以HPV16型为主（33/38 = 86.8%）。在33例AIN中，29例（87.9%）检测到HPV DNA，其中大多数为AIN III（15/16 = 93.8%）。87例均检测到HPV感染的组织学标志物。讨论本组病例中，临床诊断浸润性肛门癌的敏感性为93.6%，特异性为80%。阳性预测值为84.6%，阴性预测值为91.4%。相比之下，在临床上没有检测到AIN。在这种情况下，特别是高风险的患者，我们的研究结果建议肛门HPV筛查结合肛门细胞学和anoscopy.ConclusionBased我们的结果，我们迫切建议任何组织学报告切除肛门病变，包括一个声明是否HPV感染的组织学标志物检测。在个别情况下，必须考虑通过HPV PCR进行验证。
Background and aimsMajority of cases of anal squamous cell carcinoma are human papilloma virus (HPV)-induced and result from anal intraepithelial neoplasia (AIN). This study was conducted to examine methods which may enable the routine diagnosis of HPV-induced changes in the anal rim and the consequences of such detection especially in view of a more sensitive diagnosis of AIN. Results were clinically correlated.MethodsThe study included biopsy samples from 87 patients who had been diagnosed with the following disease patterns: 47 invasive anal carcinoma, 33 AIN of varying severity and seven condylomatous lesions. In 52 of these cases, a tumour was clinically suspected. All biopsies were retrospectively examined for microscopic indications of HPV infection. After microdissection, additional HPV analysis via PCR was carried out.ResultsIn 38 of 47 cases of anal carcinoma, HPV DNA could be detected via PCR (80.9%), the majority of which were HPV 16 (33/38=86.8%). In 29 of the 33 cases of AIN, HPV DNA was detected (87.9%), most of these in AIN III (15/16=93.8%). Histological markers of HPV infection were detected in all 87 cases.DiscussionIn our series, the clinical diagnosis of the invasive anal carcinoma had a high sensitivity of 93.6%, with a specificity of 80%. The positive predictive value was 84.6%, and the negative predictive value 91.4%. In contrast, AIN had been detected clinically in none of the cases. In this situation, especially with high-risk patients, our findings recommend anal HPV screening in combination with anal cytology and anoscopy.ConclusionBased on our results, we urgently recommend for any histological report on excision of anal lesions to include a statement whether histological markers of HPV infection were detected. In individual cases, validation via HPV PCR must be considered.
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使用涂片和细胞薄层制备对肛门上皮内瘤变进行细胞学诊断。
DOI：
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发表时间：
1995
期刊：
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.
影响因子：
--
作者：
Sherman,ME;Friedman,HB;Busseniers,AE;Kelly,WF;Carner,TC;Saah,AJ
通讯作者：
Saah,AJ
影响因子：
10.3
作者：
Frisch, M;Biggar, IJ;Goedert, JJ
通讯作者：
Goedert, JJ
影响因子：
11.2
作者：
S. Duensing;K. Münger
通讯作者：
S. Duensing;K. Münger
年轻异性恋女性肛门细胞学异常的危险因素。
DOI：
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发表时间：
1999
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Moscicki,AB;Hills,NK;Shiboski,S;Darragh,TM;Jay,N;Powell,K;Hanson,E;Miller,SB;Farhat,S;Palefsky,J
通讯作者：
Palefsky,J