ACUTE BOTULINUM-LIKE INTOXICATION BY TETANUS NEUROTOXIN IN MICE
ACUTE BOTULINUM-LIKE INTOXICATION BY TETANUS NEUROTOXIN IN MICE
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DOI：
10.1016/0006-291x(82)90708-2
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发表时间：
1982-01-01
影响因子：
3.1
通讯作者：
HIRAI, T
中科院分区：
文献类型：
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作者：
MATSUDA, M;SUGIMOTO, N;HIRAI, T
静脉注射纯化的破伤风毒素（1000-0.06 μ g）在20-450分钟内杀死小鼠，引起与肉毒杆菌中毒中的弛缓性麻痹难以区分的弛缓性麻痹：在毒素剂量的对数和死亡时间（存活时间）的对数之间发现线性关系。研究了典型的典型破伤风痉挛性麻痹和急性肉毒杆菌样弛缓性麻痹的表现与死亡时间的剂量和途径依赖性。用胰蛋白酶或神经节苷脂处理毒素不影响其急性肉毒毒素样毒性。茶碱可延缓破伤风毒素引起的类肉毒杆菌中毒小鼠的急性死亡时间，并具有一定的保护作用。
I.v. injection of purified tetanus toxin (1000-0.06 .mu.g) killed mice within 20-450 min, causing flaccid paralysis indistinguishable from that in botulinum intoxication: a linear relation was found between the log of the toxin dose and that of death time (survival time). The dose and route dependences of the manifestations of the spastic paralysis typical of classical tetanus and of the acute botulinum-like flaccid paralysis were studied in relation to the death time. Treatment of the toxin with trypsin or gangliosides did not affect its acute botulinum-like toxicity. Theophylline delayed the time of acute death due to the botulinum-like intoxication in mice caused by tetanus toxin and provided some protection.