Antimicrobial Effects of Ozone Gel Against Periodontal Bacteria
Antimicrobial Effects of Ozone Gel Against Periodontal Bacteria
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DOI：
10.2485/jhtb.23.445
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发表时间：
2014-10-01
影响因子：
0.4
通讯作者：
Wang, Pao-Li
中科院分区：
文献类型：
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作者：
Fukui, Tatsuya;Masuno, Kazuya;Wang, Pao-Li
为探讨臭氧凝胶在口腔应用的可能性，对臭氧的杀菌能力进行了检测。10ppm臭氧凝胶处理3h后淬灭和100ppm臭氧凝胶处理3h后立即淬灭对8种需氧菌，即大肠杆菌、铜绿假单胞菌、金黄色葡萄球菌、白色念珠菌、耐甲氧西林S.金黄色葡萄球菌（MRSA）、S.表皮葡萄球菌、肺炎克雷伯菌和变形链球菌。对于其中的五个菌株（E. coli、铜绿假单胞菌、C. albicans、K. pneumoniae和S.μ tans），在用10ppm臭氧凝胶处理并在3小时后淬灭后，菌落形成单位（CFU）的数量低于检测限。对于枯草芽孢杆菌，在用100 ppm臭氧凝胶处理3小时后观察到抗微生物效果。在厌氧细菌的情况下，观察杀菌效果的五个菌株，即牙龈卟啉单胞菌，中间普雷沃氏菌，具核梭杆菌，放线菌共生聚集杆菌，和腐蚀性艾肯氏菌，通过使用臭氧凝胶和臭氧霜。其中，三种菌株（牙龈卟啉单胞菌、中间卟啉单胞菌和F. nucleatum）低于检测限。这些结果表明，臭氧凝胶可以在临床上用于口腔外科植入治疗，因为它的瞬时抗菌效果，它可以用于对各种细菌菌株。
The bactericidal potency of ozone was examined for exploring the potential of dental application of ozone gel. Treatment with 10 ppm ozone gel with quenching after 3 h and treatment with 100-ppm ozone gel with immediate quenching showed antimicrobial effects in eight aerobic strains, namely, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Candidaalbicans, Methicillin-resistant S. aureus (MRSA), S. epidermidis, Klebsiella pneumoniae, and Streptococcus mutans. For five of these strains (E. coli,P aeruginosa, C. albicans, K. pneumoniae, and S. mu tans), the number of colony forming units (CFUs) were below the detection limit after treatment with 10 ppm ozone gel with quenching after 3 h. For Bacillus subtilis, an antimicrobial effect was observed after 3 h of treatment with 100 ppm of ozone gel. In the case of anaerobic bacteria, bactericidal effect was observed for five strains, namely, Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum, Aggregatibacter actinomycetemcomitans, and Eikenella corrodens, by using ozone gel and ozone cream. Of these, the number of CFUs for three strains (P. gingivalis, P. intermedia, and F. nucleatum) was below the detection limit. These results suggest that the ozone gel can be clinically useful in oral surgery for implant treatment because of its instantaneous antimicrobial effects, and that it can be used against a variety of bacterial strains.