Synergistic activity of ceftazidime-avibactam and aztreonam against serine and metallo-β-lactamase-producing gram-negative pathogens
Synergistic activity of ceftazidime-avibactam and aztreonam against serine and metallo-β-lactamase-producing gram-negative pathogens
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DOI：
10.1016/j.diagmicrobio.2017.05.009
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发表时间：
2017-08-01
影响因子：
2.9
通讯作者：
Danizger, Larry H.
中科院分区：
文献类型：
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作者：
Wenzler, Eric;Deraedt, Matthew F.;Danizger, Larry H.
本研究通过 Etest MIC:MIC 比率和琼脂-Etest 协同方法评估了头孢他啶、氨曲南和头孢他啶-阿维巴坦对产生丝氨酸和金属-β-内酰胺酶 (MBL) 的病原体的体外协同作用。氨曲南和头孢他啶-阿维巴坦的组合对所有肠杆菌科细菌具有协同作用。所测试的组合均未对产生IMP的铜绿假单胞菌具有一致的协同作用。 (C) 2017 Elsevier Inc. 保留所有权利。
This study assessed the in vitro synergy between ceftazidime, aztreonam, and ceftazidime-avibactam against serine and metallo-beta-lactamase (MBL)-producing pathogens via the Etest MIC:MIC ratio and Agar-Etest synergy methods. The combination of aztreonam and ceftazidime-avibactam was synergistic against all Enterobacteriaceae. None of the tested combinations were consistently synergistic against IMP -producing P. aeruginosa. (C) 2017 Elsevier Inc. All rights reserved.