A robust super-tough biodegradable elastomer engineered by supramolecular ionic interactions
A robust super-tough biodegradable elastomer engineered by supramolecular ionic interactions
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DOI：
10.1016/j.biomaterials.2016.01.025
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发表时间：
2016-04-01
期刊：
影响因子：
14
通讯作者：
Baharvand, Hossein
中科院分区：
文献类型：
--
作者：
Daemi, Hamed;Rajabi-Zeleti, Sareh;Baharvand, Hossein
海藻酸盐基超分子离子型聚氨酯（ASPU）作为一种机械可调的生物材料，在干燥和水合状态下都具有高强度和韧性，在无金属条件下开发。ASPU的杨氏模量和拉伸强度分别从30到100 MPa和20到50 MPa进行调节。有趣的是，ASPU在100次重复循环后表现出小的滞后回线、最小的拉伸强度损失和最小的蠕变变形，这使得它们可用于承载组织的工程化。这是第一份描述线性PU可以抵抗大量循环应力而不显著拉伸的报告。这些通过离子相互作用设计的生物基弹性体具有生物相容性和生物可降解性。与聚己内酯（PCL）相比，ASPU的体内降解速率相似。这些生物材料还表现出在破裂后的快速自愈和恢复，并且具有线性生物降解特征。此外，5个月后皮下移植ASPU的组织学检查显示低免疫应答和低纤维化。(C)2016由Elsevier Ltd.出版
Alginate-based supramolecular ionic polyurethanes (ASPUs) as mechanically tunable biomaterials with high strength and toughness in both dry and hydrated states are developed under metal-free conditions. The Young's modulus and tensile strength of ASPUs are tuned from 30 to 100 MPa, and 20 to 50 MPa, respectively. Interestingly, the ASPUs exhibit a small hysteresis loop, minimal loss of tensile strength and minimal creep deformation after 100 repetitive cycles which makes them of use for engineering of load bearing tissues. This is the first report that describes a linear PU can resist a large number of cyclic stresses without significant stretching. These bio-based elastomers engineered by ionic interactions are biocompatible and biodegradable. The ASPUs demonstrate a similar in vivo degradation rate compared to polycaprolactone (PCL). These biomaterials also demonstrate a rapid self-healing and recovery after rupture, and have a linear biodegradation profile. Furthermore, histological examination of subcutaneous transplanted ASPUs after five months reveals low immunological response and low fibrosis. (C) 2016 Published by Elsevier Ltd.