NONSPECIFIC AND SPECIFIC ACTIVE IMMUNOTHERAPY IN A B-16 MURINE MELANOMA SYSTEM
NONSPECIFIC AND SPECIFIC ACTIVE IMMUNOTHERAPY IN A B-16 MURINE MELANOMA SYSTEM
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DOI：
10.1002/jso.2930120111
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发表时间：
1979-01-01
影响因子：
2.5
通讯作者：
SEIGLER, HF
中科院分区：
文献类型：
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作者：
AVENT, J;VERVAERT, C;SEIGLER, HF
关于免疫治疗的非特异性和特异性尝试的功效的冲突可归因于利用不同免疫原性的肿瘤的不同动物模型。选择B16小鼠黑色素瘤模型作为与宿主组织相容并具有肿瘤相关抗原的自发发生的肿瘤的实例。尝试用非特异性主动免疫疗法[BCG和痤疮丙酸杆菌]以及特异性主动免疫疗法[霍乱弧菌神经酰胺酶和丝裂霉素C处理的肿瘤细胞]来改变肿瘤生长或存活率是不成功的。非特异性主动预免疫未能改变肿瘤的摄取或生长。特异性主动免疫治疗与佐剂和无肿瘤采取和延长宿主生存。在较低的肿瘤细胞接种量下，效果非常明显，并且随着肿瘤细胞攻击的增加而变得不那么明显。
Conflicts concerning the efficacy of both nonspecific and specific attempts at immunotherapy may be ascribed to different animal models utilizing tumors of different immunogenicity. The B16 mouse melanoma model was selected as the example of a spontaneously occurring neoplasm that is histocompatible with the host and has tumor-associated antigens. Attempts to alter tumor growth or survival with nonspecific active immunotherapy [BCG and Propionibacterium acnes] as well as with specific active immunotherapy [Vibrio cholerae neuramidase and mitomycin C treated tumor cells] were unsuccessful. Nonspecific active pre-immunization failed to alter tumor take or growth. Specific active immunotherapy with and without adjuvant decreased tumor take and prolonged host survival. The effects were very apparent at lower tumor cell inocula and became less apparent with increase in the tumor cell challenge.