Increased expression of matrix metalloproteinase-7 in invasive early gastric cancer
Increased expression of matrix metalloproteinase-7 in invasive early gastric cancer
复制标题
DOI：
10.1007/s00535-003-1316-3
复制
发表时间：
2004-05-01
影响因子：
6.3
通讯作者：
Okita, K
中科院分区：
文献类型：
--
作者：
Kitoh, T;Yanai, H;Okita, K
背景基质金属蛋白酶-7（MMP-7）是一种蛋白水解酶，被怀疑在多种癌症的进展中起重要作用。为了阐明MMP-7的临床意义，我们回顾性分析了MMP-7在胃上皮性肿瘤中的表达。方法.我们测试了201个病变（来自172名患者）手术或内镜切除的胃上皮肿瘤（胃癌，158个病变;胃腺瘤，32个病变;增生性息肉，11个病变）。免疫组化法检测MMP-7表达。在30%以上的肿瘤细胞中具有免疫染色信号的切片被判定为显示阳性表达。结果MMP-7阳性表达率为33.3%（67/201）。MMP-7在弥漫型腺癌中的阳性表达率（62.2%; 28/45）明显高于浸润型腺癌（31.9%; 36/113; P
Background. Matrix metalloproteinase-7 (MMP-7), a proteolytic enzyme, is suspected to play an important role in the progression of various cancers. To clarify the clinical importance of MMP-7, we retrospectively analyzed MMP-7 expression in gastric epithelial tumors. Methods. We tested 201 lesions (from 172 patients) of surgically or endoscopically resected gastric epithelial tumors (gastric cancer, 158 lesions; gastric adenoma, 32 lesions; hyperplastic polyp, 11 lesions). MMP-7 expression was immunohistochemically examined. Sections with immunostaining signals in more than 30% of tumor cells were judged to show positive expression. Results. MMP-7 was expressed in 33.3% (67/201) of all lesions. MMP-7-positive tumors were significantly more frequent in diffuse-type adenocarcinomas (62.2%; 28/45) compared with intestinal-type lesions (31.9%; 36/113; P