CONCENTRATIONS OF NEUROPEPTIDES SUBSTANCE-P, NEUROKININ-A, CALCITONIN GENE-RELATED PEPTIDE, NEUROPEPTIDE-Y AND VASOACTIVE INTESTINAL POLYPEPTIDE IN SYNOVIAL-FLUID OF THE HUMAN TEMPOROMANDIBULAR-JOINT - A CORRELATION WITH SYMPTOMS, SIGNS AND ARTHROSCOPIC FINDINGS
CONCENTRATIONS OF NEUROPEPTIDES SUBSTANCE-P, NEUROKININ-A, CALCITONIN GENE-RELATED PEPTIDE, NEUROPEPTIDE-Y AND VASOACTIVE INTESTINAL POLYPEPTIDE IN SYNOVIAL-FLUID OF THE HUMAN TEMPOROMANDIBULAR-JOINT - A CORRELATION WITH SYMPTOMS, SIGNS AND ARTHROSCOPIC FINDINGS
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DOI：
10.1016/s0901-5027(05)80181-x
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发表时间：
1991-08-01
影响因子：
2.4
通讯作者：
THEODORSSON, E
中科院分区：
文献类型：
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作者：
HOLMLUND, A;EKBLOM, A;THEODORSSON, E
对18例(19个关节)颞下颌关节病患者进行了关节镜检查。关节镜检查发现有12例患者存在关节盘紊乱，其中3例为类风湿性关节炎。6名患者患有骨关节病，包括1名类风湿性关节炎患者。用放射免疫法测定滑液中P物质样免疫活性物质(SP-LI)、神经激肽A(NKA-LI)、降钙素基因相关肽(CGRP-LI)、神经肽Y(NPY-LI)和血管活性肠肽(VIP-LI)的含量。所有被分析的多肽都在不同的关节中被发现，尽管浓度不同。不同组别患者滑液中的多肽浓度无显著差异。临床症状和体征、关节镜检查结果或止痛/消炎药物的使用与滑液中的多肽浓度之间没有明显的相关性。与早期发现的膝关节相比，TMJ中SP-LI、CGRP-LI和NPY-LI的浓度显著升高。
Arthroscopy was performed on 18 patients (19 joints) with temporomandibular joint arthropathy. Arthroscopic investigation revealed that 12 patients had disk derangement, including 3 patients with rheumatoid arthritis. Six patients had osteoarthrosis, including one patient with rheumatoid arthritis. Synovial fluid content of substance P-like immunoreactivity (SP-LI), neurokinin A (NKA-LI), calcitonin gene-related peptide (CGRP-LI), neuropeptide Y (NPY-LI) and vasoactive intestinal polypeptide (VIP-LI) were analysed using radioimmunoassay technique. All peptides analysed were found, although in various concentrations, in the different joints. There were no significant differences in concentrations of the peptides in the synovial fluid between patients in the various groups. No significant correlation was found between clinical symptoms and signs, arthroscopic findings, or use of analgesic/anti-inflammatory medication versus concentrations of peptides in the synovial fluid. In comparison with earlier findings in the knee joint significantly higher concentrations of SP-LI, CGRP-LI and NPY-LI were found in the TMJ.