Changes in audiometric threshold and frequency selectivity correlate with cochlear histopathology in macaque monkeys with permanent noise-induced hearing loss.
Changes in audiometric threshold and frequency selectivity correlate with cochlear histopathology in macaque monkeys with permanent noise-induced hearing loss.
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DOI：
10.1016/j.heares.2020.108082
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发表时间：
2020-12
期刊：
影响因子：
2.8
通讯作者：
Ramachandran R
中科院分区：
文献类型：
--
作者：
Burton JA;Mackey CA;MacDonald KS;Hackett TA;Ramachandran R
暴露于高噪音会导致内耳损伤，包括但不限于外毛细胞和内毛细胞（OHC和IHS）以及IHS带状突触。这种耳蜗损伤损害听觉处理并增加听力阈值（噪声性听力损失，NIHL）。然而，NIHL的感知后果和其潜在的耳蜗病理学之间的确切关系知之甚少。本研究使用了非人灵长类动物模型NIHL与耳蜗组织病理学指数的频率选择性和听力阈值的变化。三只猕猴（一只猕猴和两只猕猴）被训练在安静的环境中和在音调频率周围频谱陷波的噪音中检测音调。听力图来自于安静时的音调阈值;感知听觉滤波器来自于使用四舍五入指数拟合的陷波噪声掩蔽者的音调阈值。在暴露于中心频率为2 kHz、声压级为141或146 dB的50 Hz噪声4小时之前和之后获得数据。噪声暴露导致永久性听力阈值偏移和2 kHz及以上的听觉滤波器加宽，146 dB暴露的猴子观察到更大的变化。感知听觉滤波器的归一化带宽与每个音调频率下的测听阈值密切相关。虽然测听阈值和感知听觉滤波器宽度的变化主要由OHC存活的程度决定，但通过OHC、IHC和带状突触存活之间的相互作用来解释额外的变异性。这是第一项研究，以提供在NIHL动物模型中的听觉滤波器带宽的受试者内比较，并将这些NIHL相关的感知变化与耳蜗组织病理学相关。这些结果扩大了正在进行的调查的神经相关的NIHL相关的感知变化的基础。
Exposure to loud noise causes damage to the inner ear, including but not limited to outer and inner hair cells (OHCs and IHCs) and IHC ribbon synapses. This cochlear damage impairs auditory processing and increases audiometric thresholds (noise-induced hearing loss, NIHL). However, the exact relationship between the perceptual consequences of NIHL and its underlying cochlear pathology are poorly understood. This study used a nonhuman primate model of NIHL to relate changes in frequency selectivity and audiometric thresholds to indices of cochlear histopathology. Three macaques (one Macaca mulatta and two Macaca radiata) were trained to detect tones in quiet and in noises that were spectrally notched around the tone frequency. Audiograms were derived from tone thresholds in quiet; perceptual auditory filters were derived from tone thresholds in notched-noise maskers using the rounded-exponential fit. Data were obtained before and after a four-hour exposure to a 50-Hz noise centered at 2 kHz at 141 or 146 dB SPL. Noise exposure caused permanent audiometric threshold shifts and broadening of auditory filters at and above 2 kHz, with greater changes observed for the 146-dB-exposed monkeys. The normalized bandwidth of the perceptual auditory filters was strongly correlated with audiometric threshold at each tone frequency. While changes in audiometric threshold and perceptual auditory filter widths were primarily determined by the extent of OHC survival, additional variability was explained by including interactions among OHC, IHC, and ribbon synapse survival. This is the first study to provide within-subject comparisons of auditory filter bandwidths in an animal model of NIHL and correlate these NIHL-related perceptual changes with cochlear histopathology. These results expand the foundations for ongoing investigations of the neural correlates of NIHL-related perceptual changes.
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作者：
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