Using structure to define the function of phosphoinositide 3-kinase family members
Using structure to define the function of phosphoinositide 3-kinase family members
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DOI：
10.1016/s0014-5793(97)00617-0
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发表时间：
1997-06-23
期刊：
影响因子：
3.5
通讯作者：
Waterfield, MD
中科院分区：
文献类型：
--
作者：
Domin, J;Waterfield, MD
现在已经清楚，脂质磷酸化和水解在细胞外刺激跨细胞质的传递中起着关键作用 [1, 2]。因此，人们付出了巨大的努力来表征负责这些信号事件的酶[3-5]。本文将概述脂质激酶的一个家族；即磷酸肌醇 3-激酶 (PI3-激酶)，其存在于从粘菌到人类的各种物种中，并催化磷酸盐添加到磷酸肌醇的肌醇环上的 3' 位。我们主要根据结构对数量迅速增加的 PI3 激酶家族成员进行分类，并讨论我们对其调控和下游目标的理解。通过这种方式，我们希望提供一个框架，使 PI3 激酶家族成员的命名得以标准化。
It is now clear that lipid phosphorylation and hydrolysis plays a pivotal role in the transmission of extracellular stimuli across the cytoplasm [1, 2]. Consequently, great effort has been applied to characterize the enzymes responsible for these signalling events [3-5]. This article will present an overview of one family of lipid kinases; namely the phosphomositide 3-kinases (PI3-kinases) which are found in species ranging from slime mold to man and catalyse the addition of phosphate to the 3'position on the inositol ring of phosphoinositides. We offer a classification of the rapidly expanding number of PI3-kinase family members based principally on their structure and discuss our understanding of their regulation and downstream targets. In this way we hope to provide a framework within which the nomenclature of PI3-kinase family members can be standardised.