Role of polyunsaturated fatty acids for misfolding protein aggregations - Implication for neurodegenerative diseases
Role of polyunsaturated fatty acids for misfolding protein aggregations - Implication for neurodegenerative diseases
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DOI：
10.1196/annals.1377.021
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发表时间：
2006-01-01
期刊：
影响因子：
--
通讯作者：
Takahashi, Ryosuke
中科院分区：
文献类型：
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作者：
Kim, Yeon-Jeong;Takahashi, Ryosuke
许多神经退行性疾病都伴随着特征性神经元群内高度不溶的蛋白质聚集体内含物。最近的体外研究推进了蛋白质聚集体及其细胞毒性的新方面。未折叠蛋白质的聚集体逃脱了细胞质量控制系统，例如分子伴侣和蛋白酶体，这是聚集体相关的本氏降解的一个共同特征。基于这个想法，有几个因素可能提供有利于蛋白质聚集的条件，这些条件与疾病的进展密切相关。我们特别关注多不饱和脂肪酸作为与疾病发病机制相关的未折叠蛋白质聚集的重要调节剂。
Numerous neurodegenerative diseases are accompanied by highly insoluble inclusions of protein aggregates within characteristic neuronal populations. Recent in vitro studies have advanced new aspects of protein aggregates and their cytotoxicity. Aggregations of unfolded proteins escape the cellular quality-control system, such as chaperone and proteasome, which is a common feature of aggregates-associated Ben rodegene ration. Based on this idea, several factors may provide protein aggregates-favoring conditions that are closely involved in progression of diseases. In particular, we focused on polyunsaturated fatty acids as an important modulator for unfolded protein-aggregation in relation to disease pathogenesis.