Viscoelastic properties of three vocal-fold injectable biomaterials at low audio frequencies
Viscoelastic properties of three vocal-fold injectable biomaterials at low audio frequencies
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DOI：
10.1097/00005537-200409000-00018
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发表时间：
2004-09-01
期刊：
影响因子：
2.6
通讯作者：
Titze, IR
中科院分区：
文献类型：
--
作者：
Klemuk, SA;Titze, IR
目的：以前的测量Zyderm的粘弹性能被扩展到低音频频率，和其他两种生物材料的性能以前没有测量，巯基化透明质酸（HA-DTPH）和Cymetra，获得。研究设计：流变学研究。研究方法：使用受控应力流变仪以0.01和100 Hz之间的频率用平行板装置向每个样品施加振荡剪切应力。在每个频率下记录抗弹性模量。然后使用计算出的机器和样品的共振频率来确定存在可靠数据的最大频率。将外推函数拟合到粘弹性参数，其预测高达1，000 Hz的特性。结果：Zyderm的频率趋势与以前报道的相似，但幅度不同。弹性模量随频率的增加而增加，而动态粘度表现出剪切稀化，这是人类在宽频率范围内发声的首要条件。以前的测量从15 Hz扩展到74 Hz。先前研究和本研究之间的幅度差异归因于试验期间的颗粒方向。Cymetra被发现具有几乎相同的粘弹性的牛胶原蛋白，无论是在幅度和频率趋势，与可靠的措施延伸到81赫兹。透明质酸凝胶的流变特性在幅度和频率趋势上与尸体声带粘膜最接近。结论. Cymetra和Zyderm的粘弹性几乎相同，并且显著大于声带粘膜的粘弹性。HA-DTPH具有良好的粘弹性匹配声带粘膜，并可能是有用的，在未来的固有层修复。
Objectives: Previous measurements of viscoelastic properties of Zyderm were to be extended to low audio frequencies, and properties of two other biomaterials not previously measured, thiolated hyaluronic acid (HA-DTPH) and Cymetra, were obtained. Study Design: Rheologic investigation. Methods: Oscillatory shear stress was applied to each sample using a controlled stress rheometer at frequencies between 0.01 and 100 Hz with a parallel plate apparatus. Versuscoelastic moduli were recorded at each frequency. The calculated resonance frequency of the machine and sample were then used to determine the maximum frequency at which reliable data existed. Extrapolation functions were fit to viscoelastic parameters, which predicted the properties up to 1,000 Hz. Results: Frequency trends of Zyderm were similar to those previously reported, whereas magnitudes were different. The elastic moduli logarithmically increased with frequency, whereas dynamic viscosity demonstrated shear thinning, a condition of primary importance for humans to vocalize over a broad frequency range. Previous measurements were extended from 15 Hz up to 74 Hz. Differences in magnitude between a previous study and the present study were attributed to particulate orientation during testing. Cymetra was found to have nearly identical viscoelastic properties to those of bovine collagen, both in magnitude and frequency trend, with reliable measures extending up to 81 Hz. Rheologic properties of the hyaluronic acid gel were the closest match to cadaveric vocal fold mucosa in magnitude and frequency trend. Conclusions. Viscoelastic properties of Cymetra and Zyderm are nearly the same and are significantly greater than those of vocal fold mucosa. HA-DTPH possesses a good viscoelastic match to vocal fold mucosa and may be useful in future lamina propria repair.