Colorado surveillance program for chronic wasting disease transmission to humans - Lessons from 2 highly suspicious but negative cases
Colorado surveillance program for chronic wasting disease transmission to humans - Lessons from 2 highly suspicious but negative cases
复制标题
DOI：
10.1001/archneur.64.3.439
复制
发表时间：
2007-03-01
影响因子：
--
通讯作者：
Tyler, Kenneth L.
中科院分区：
文献类型：
--
作者：
Anderson, C. Alan;Bosque, Patrick;Tyler, Kenneth L.
目的：描述2例快速发展的痴呆症患者和暴露于慢性消耗性疾病(CWD)的危险因素，在这些患者中，广泛的测试否定了CWD传播的可能性。设计/方法：我们描述了2名年轻人的评估，这些患者最初有接触CWD的病史和临床表现，表明CWD可能传播给人类。患者：1名可能在实验室接触CWD的52岁女性和1名25岁的男性，曾食用CWD流行区的肉类。干预：临床评估，神经病理学检查，结果：2例患者的神经病理和遗传学评估证实为早发性阿尔茨海默病和一种罕见的遗传性Pron病。结论：在我们的监测项目中，没有发现令人信服的CWD传播给人类的病例。
Objective: To describe 2 patients with rapidly progressive dementia and risk factors for exposure to chronic wasting disease (CWD) in whom extensive testing negated the possible transmission of CWD.Design/Methods: We describe the evaluation of 2 young adults with initial exposure histories and clinical presentations that suggested the possibility of CWD transmission to humans.Patients: A 52-year-old woman with possible laboratory exposure to CWD and a 25-year-old man who had consumed meat from a CWD endemic area.Interventions: Clinical evaluation, neuropathological examination, and genetic testing.Results: Neuropathological and genetic assessment in the 2 patients proved the diagnoses of early-onset Alzheimer disease and a rare genetic prion disease.Conclusion: No convincing cases of CWD transmission to humans have been detected in our surveillance program.