The Role of Copper Chaperone Atox1 in Coupling Redox Homeostasis to Intracellular Copper Distribution.
The Role of Copper Chaperone Atox1 in Coupling Redox Homeostasis to Intracellular Copper Distribution.
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DOI：
10.3390/antiox5030025
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发表时间：
2016-07-27
期刊：
影响因子：
--
通讯作者：
Lutsenko S
中科院分区：
文献类型：
--
作者：
Hatori Y;Lutsenko S
人类抗氧化蛋白1(Atox1)是一种小的胞质蛋白，在铜的稳态中起着重要的作用。Atox1作为铜载体，促进铜向分泌途径的转移。这一过程是激活铜依赖的酶所必需的，这些酶参与神经递质的生物合成、铁的外流、新生血管、伤口愈合和血压调节。最近，Atox1的新的细胞角色已经出现。Atox1水平的变化被证明调节了对癌症治疗的反应，促进了炎症反应，并保护细胞免受各种氧化应激的影响。也很明显，Atox1的活性与细胞的氧化还原状态密切相关。在这篇综述中，我们总结了与Atox1作为铜伴侣和抗氧化剂的双重作用有关的生化信息。我们讨论了这两种活动是如何联系在一起的，并有助于在分化过程中建立细胞内铜平衡和功能同一性。
Human antioxidant protein 1 (Atox1) is a small cytosolic protein with an essential role in copper homeostasis. Atox1 functions as a copper carrier facilitating copper transfer to the secretory pathway. This process is required for activation of copper dependent enzymes involved in neurotransmitter biosynthesis, iron efflux, neovascularization, wound healing, and regulation of blood pressure. Recently, new cellular roles for Atox1 have emerged. Changing levels of Atox1 were shown to modulate response to cancer therapies, contribute to inflammatory response, and protect cells against various oxidative stresses. It has also become apparent that the activity of Atox1 is tightly linked to the cellular redox status. In this review, we summarize biochemical information related to a dual role of Atox1 as a copper chaperone and an antioxidant. We discuss how these two activities could be linked and contribute to establishing the intracellular copper balance and functional identity of cells during differentiation.
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DOI：
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发表时间：
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影响因子：
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