Elevated endocannabinoid plasma levels are associated with coronary circulatory dysfunction in obesity
Elevated endocannabinoid plasma levels are associated with coronary circulatory dysfunction in obesity
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DOI：
10.1093/eurheartj/ehr029
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发表时间：
2011-06-01
影响因子：
39.3
通讯作者：
Schindler, Thomas H.
中科院分区：
文献类型：
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作者：
Quercioli, Alessandra;Pataky, Zoltan;Schindler, Thomas H.
本研究的目的是评估内源性大麻素（EC）的血浆水平，如大麻素（AEA）和2-花生四烯酰甘油（2-AG），和冠状动脉循环功能在肥胖症。方法和结果心肌血流量（MBF）的反应冷加压试验（CPT）和在药理学血管舒张与潘生丁（13）N-氨PET/CT测量。研究参与者（n = 77）根据他们的体重指数（BMI，kg/m2）分为三组：对照组20
Aims Aim of this study was to evaluate a possible association between endocannabinoid (EC) plasma levels, such as anandamide (AEA) and 2-arachidonoylglycerol (2-AG), and coronary circulatory function in obesity.Methods and results Myocardial blood flow (MBF) responses to cold pressor test (CPT) and during pharmacological vasodilation with dipyridamole were measured with (13)N-ammonia PET/CT. Study participants (n = 77) were divided into three groups based on their body mass index (BMI, kg/m(2)): control group 20