Opioid equianalgesic calculations.
Opioid equianalgesic calculations.
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DOI：
10.1089/jpm.1999.2.209
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发表时间：
1999-01-01
影响因子：
2.8
通讯作者：
Ford-Roberts, K
中科院分区：
文献类型：
--
作者：
Gordon, D B;Stevenson, K K;Ford-Roberts, K
在医疗保健专业人员管理疼痛所需的知识中，有一项是了解阿片类药物和制剂之间的差异。随着新的阿片类药物配方的不断增加，临床医生了解这些止痛药的基本药理以及如何计算等量的止痛剂变得越来越重要。给予同等剂量的止痛剂会增加向另一种阿片类药物或路线过渡的可能性，而不会失去疼痛控制或过度副作用。虽然等止痛剂剂量的计算需要相对简单的数学技能，但很少有临床医生准备计算它们。本文的目的是提供阿片类药物药理学的基本综述，解释如何计算等效镇痛剂剂量，并简要描述目前关于阿片类药物在等效性镇痛表中的相对效力的一些争议。
Among the knowledge required by healthcare professionals to manage pain is an understanding of the differences between opioid agents and formulations. As the list of new opioid formulations continues to grow, it is increasingly important that clinicians understand the basic pharmacology of these analgesics and how to calculate equianalgesic doses. Administering an equianalgesic dose increases the likelihood that the transition to another opioid or route will be tolerated without loss of pain control or excessive side effects. Although calculation of equianalgesic doses requires relatively simple mathematical skills, few clinicians are prepared to compute them. The purpose of this article is to provide a basic review of the pharmacology of opioids, explain how to calculate an equianalgesic dose, and briefly describe some of the current controversies of the relative potencies of opioids listed in equianalgesic tables.