Association between genetic variants in the XPG gene and gastric cancer risk in a Southern Chinese population.
Association between genetic variants in the XPG gene and gastric cancer risk in a Southern Chinese population.
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XPG 基因的遗传变异与中国南方人群胃癌风险之间的关联。
DOI：
10.18632/aging.101119
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发表时间：
2016-12-06
期刊：
影响因子：
--
通讯作者：
He J
中科院分区：
文献类型：
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作者：
Hua RX;Zhuo ZJ;Zhu J;Jiang DH;Xue WQ;Zhang SD;Zhang JB;Li XZ;Zhang PF;Jia WH;Shen GP;He J
着色性干皮病G组（XPG）在DNA修复过程中识别和切除3 '侧的DNA损伤。既往研究提示XPG基因多态性可能与胃癌易感性相关，但结果不一致。我们在1142例胃癌患者和1173例对照中评估了5个潜在功能的XPG多态性（rs2094258 C>T、rs751402 C>T、rs2296147 T>C、rs1047768 T>C和rs873601 G>A）与胃癌易感性的关系。采用logistic回归模型计算比值比（ORs）和95%置信区间（ci）。总的来说，没有发现任何选择的多态性与胃癌风险之间的显著关联。然而，我们发现携带3-4个危险基因型的个体发生胃癌的风险明显高于携带0-2个危险基因型的个体（OR=1.32, 95% CI=1.04-1.68， P=0.021）。分层分析显示，风险基因型（3-4 vs 0-2）对胃癌的累积效应在年龄大于58岁的亚组和男性中更为突出。总之，我们的结果表明，所选择的XPG多态性都不能单独显著改变胃癌的易感性。这些多态性可能共同增加了胃癌的易感性。这些发现将通过涉及不同种族人群的更大规模的前瞻性多中心研究得到加强。
Xeroderma pigmentosum group G (XPG) recognizes and excises DNA damage on the 3′ side during the DNA repair process. Previous studies indicated that XPG gene polymorphisms may associate with gastric cancer susceptibility, but results were inconsistent. We evaluated the association of five potentially functional XPG polymorphisms (rs2094258 C>T, rs751402 C>T, rs2296147 T>C, rs1047768 T>C, and rs873601 G>A) with gastric cancer susceptibility in 1142 gastric cancer cases and 1173 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression models. Overall, no significant association was detected between any of selected polymorphism and gastric cancer risk. However, we found that individuals carrying 3-4 risk genotypes were at significantly higher risk of gastric cancer than those with 0-2 risk genotypes (OR=1.32, 95% CI=1.04-1.68, P=0.021). The stratification analysis revealed that the cumulative effect of risk genotypes (3-4 vs. 0-2) on gastric cancer were more prominent among subgroups older than 58 years and men. In conclusion, our results indicated that none of the selected XPG polymorphism could significantly alter gastric cancer susceptibility alone. These polymorphisms might collectively confer increased gastric cancer susceptibility. These findings would be strengthened by larger prospective multicenter studies involving different ethnic populations.