Hypolipidaemic effects of n-3 fatty acids in primary hyperlipoproteinaemia.
Hypolipidaemic effects of n-3 fatty acids in primary hyperlipoproteinaemia.
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n-3 脂肪酸对原发性高脂蛋白血症的降血脂作用。
DOI：
10.1111/j.1365-2796.1989.tb01441.x
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Harris,WS
中科院分区：
文献类型：
--
作者：
Illingworth,DR;Connor,WE;Hatcher,LF;Harris,WS
本文综述了富含n-3脂肪酸的鱼油对原发性高脂蛋白血症患者血脂和脂蛋白浓度的影响。当用作膳食补充剂时，n-3脂肪酸对富含甘油三酯的脂蛋白的浓度产生最大影响，这些影响具有剂量依赖性。低剂量n-3脂肪酸可降低IV型、V型和IIB型高脂蛋白血症患者的血浆甘油三酯浓度，但同时导致低密度脂蛋白（LDL）血浆浓度适度升高。使用非常高的剂量，IIB型表型患者的LDL胆固醇血浆浓度降低。在低剂量下，n-3脂肪酸不会显着降低原发性高胆固醇血症患者的LDL胆固醇浓度，而在较高剂量下，可以实现适度的降低LDL胆固醇的作用。结果表明，n-3脂肪酸作为降血脂剂在高血脂症患者中的治疗潜力最大。
The influence of fish oils rich in n‐3 fatty acids on plasma lipid and lipoprotein concentrations in patients with primary hyperlipoproteinaemia is reviewed. When used as a dietary supplement, n‐3 fatty acids exert their greatest effect on the concentrations of triglyceride‐rich lipoproteins and these effects are dose dependent. Low doses of n‐3 fatty acids reduce plasma triglyceride concentrations in patients with phenotypic type IV, type V and type IIB hyperlipoproteinaemia, but concurrently result in modest increases in the plasma concentrations of low density lipoprotein (LDL). With very high doses plasma concentrations of LDL cholesterol decrease in patients with the type IIB phenotype. At low doses n‐3 fatty acids do not significantly lower concentrations of LDL cholesterol in patients with primary hypercholesterolaemia whereas at higher doses a modest LDL lowering effect is achieved. The results indicate that the therapeutic potential of n‐3 fatty acids as hypolipidaemic agents is greatest in patients with hypertriglyceridaemia.