Clinical effects of the dichloro and monochlorophenyl analogues of diamino pyrimidine: antagonists of folic acid.
Clinical effects of the dichloro and monochlorophenyl analogues of diamino pyrimidine: antagonists of folic acid.
复制标题
二氨基嘧啶的二氯和一氯苯基类似物的临床效果：叶酸拮抗剂。
DOI：
10.1172/jci103016
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发表时间：
1954
期刊：
影响因子：
--
通讯作者：
Joseph H. Burchenal
中科院分区：
文献类型：
--
作者：
Murphy Ml;Ellison Rr;Karnofsky Da;Joseph H. Burchenal
HN S N CH: 2, 4-diamino-5-(3', 4'-dichlorophenyl)-6-methylpyrimidine (DDMP) thus similar to those of the 4 amino derivatives of folic acid. But in contrast to the folic acid antago-nists, the active pyrimidines are not pterins, and it appears unlikely that a rearrangement or structural alteration to a pterin ring system can occur. It is of interest, however, that high antagonist
