Neural substrate of the late positive potential in emotional processing.
Neural substrate of the late positive potential in emotional processing.
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晚期积极潜力在情绪处理中的神经基材。
DOI：
10.1523/jneurosci.3109-12.2012
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发表时间：
2012-10-17
期刊：
影响因子：
--
通讯作者：
Ding M
中科院分区：
文献类型：
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作者：
Liu Y;Huang H;McGinnis-Deweese M;Keil A;Ding M
晚正电位（LPP）是人类情绪感知的可靠电生理指标。尽管多年的研究，大脑结构，有助于产生和调制的LPP没有得到很好的理解。同时记录EEG和fMRI，并应用最近提出的单次试验ERP分析方法，我们通过将情感图片诱发的单次试验LPP幅度与血氧水平依赖（BOLD）活动相关联来解决这个问题。研究发现了三个结果：第一，相对于中性图片，令人愉快和不愉快的图片会引发增强的LPP，以及视觉皮层和情绪处理结构（如杏仁核和前额叶皮层）中BOLD活动的增强，这与之前的研究结果一致。第二，三种图片类别的LPP幅度与视觉皮层、颞叶皮层、杏仁核、眶额皮层和杏仁核的BOLD活动显著相关。第三，在每个图片类别内，LPP-BOLD耦合揭示了类别特定的差异。对于愉快的图片，LPP振幅耦合与BOLD在枕颞交界处，内侧前额叶皮层，杏仁核，楔前叶，而不愉快的图片，显着的LPP-BOLD相关观察到腹外侧前额叶皮层，杏仁核，和后扣带皮层。这些结果表明，LPP产生和调制的广泛的大脑网络组成的皮层和皮层下结构与视觉和情绪处理和这些结构的LPP调制的贡献程度是价特异性的。
The late positive potential (LPP) is a reliable electrophysiological index of emotional perception in humans. Despite years of research the brain structures that contribute to the generation and modulation of LPP are not well understood. Recording EEG and fMRI simultaneously, and applying a recently proposed single-trial ERP analysis method, we addressed the problem by correlating the single-trial LPP amplitude evoked by affective pictures with the blood-oxygen-level-dependent (BOLD) activity. Three results were found. First, relative to neutral pictures, pleasant and unpleasant pictures elicited enhanced LPP, as well as heightened BOLD activity in both visual cortices and emotion-processing structures such as amygdala and prefrontal cortex, consistent with previous findings. Second, the LPP amplitude across three picture categories was significantly correlated with BOLD activity in visual cortices, temporal cortices, amygdala, orbitofrontal cortex, and insula. Third, within each picture category, LPP-BOLD coupling revealed category-specific differences. For pleasant pictures, the LPP amplitude was coupled with BOLD in occipitotemporal junction, medial prefrontal cortex, amygdala, and precuneus, whereas for unpleasant pictures, significant LPP-BOLD correlation was observed in ventrolateral prefrontal cortex, insula, and posterior cingulate cortex. These results suggest that LPP is generated and modulated by an extensive brain network comprised of both cortical and subcortical structures associated with visual and emotional processing and the degree of contribution by each of these structures to the LPP modulation is valence-specific.