The Polymorphic Forms of α1-Acid Glycoprotein of Normal Caucasian Individuals*
The Polymorphic Forms of α1-Acid Glycoprotein of Normal Caucasian Individuals*
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正常白种人的 α1-酸性糖蛋白的多态性*
DOI：
10.1172/jci105108
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发表时间：
1964
影响因子：
15.9
通讯作者：
H. Yoshizaki
中科院分区：
文献类型：
--
作者：
K. Schmid;J. Binette;K. Tokita;L. Moroz;H. Yoshizaki
Al-酸性糖蛋白(2，3)是人类血浆中纯度最高的蛋白之一，在等电点附近的淀粉凝胶电泳图上表现出多态。从混合正常血中分离到7条带(4)。这种蛋白质的一些多态形式的化学和物理化学性质被发现非常相似，而在其他方面观察到显著的差异(5)。本文介绍了α-酸性糖蛋白多态性的遗传学方面的研究。具体地说，这项调查是为了确定正常的高加索人是否具有不同的α-酸性糖蛋白特征，其特征是淀粉凝胶电泳谱的条带数量不同。
al-Acid glycoprotein (2, 3), one of the most highly purified human plasma proteins, appears polymorphic on starch gel electrophoresis near its isoelectric point. \Vhen isolated from pooled normal blood it reveals seven bands (4). Some of the chemical and physical chemical properties of the polymorphic forms of this protein have been found to be very similar, whereas significant differences were observed with respect to others (5). In the present paper, studies on the genetic aspects of the polymorphism of a,-acid glycoprotein are described. Specifically, this investigation has been carried out to determine whether normal Caucasian individuals possess different a,-acid glycoprotein traits characterized by different numbers of bands of the starch gel electrophoretic patterns.