The effect of 0.5% ropivacaine on epidural blood flow.
The effect of 0.5% ropivacaine on epidural blood flow.
复制标题
%20%20效果%20%200.5%%20罗哌卡因%20对%20硬膜外%20血液%20流。
DOI：
10.1097/00132582-199010000-00035
复制
发表时间：
1990
影响因子：
2.1
通讯作者：
H. Kehlet
中科院分区：
文献类型：
--
作者：
J. Dahl;L. Simonsen;T. Mogensen;J. Henriksen;H. Kehlet
20例择期腹部手术患者接受0.5%罗哌卡因或0.5%布比卡因20 ml硬膜外镇痛。在手术前一天（无局部麻醉剂）和手术前1小时、连续输注（8 ml/h）期间注射局部麻醉剂后30 min，通过硬膜外133 μ m清除技术测量硬膜外血流量。在接受罗哌卡因和布比卡因的患者中，平均初始血流量分别为5.0 ml/min和6.0 ml/min/100 g组织。在硬膜外布比卡因后，10例患者中有8例的血流量增加至6.9 ml/min/100 g组织（P <0.05），而罗哌卡因后10例患者中有9例的血流量下降至3.3 ml/min/100 g组织（P <0.05），（两组间P <0.01）。罗哌卡因组和布比卡因组感觉镇痛的中位水平分别为T3.5和T4.5（P> 0.05）。硬膜外罗哌卡因的血管收缩作用可能影响其局部麻醉作用的持续时间。
Twenty patients scheduled for elective abdominal surgery received epidural analgesia with 20 ml 0.5% ropivacaine or 0.5% bupivacaine. Epidural blood flow was measured by an epidural 133Xe clearance technique on the day before surgery (no local anaesthetic) and again 1 h before surgery, 30 min after injection of the local anaesthetic during continuous infusion (8 ml/h). Median initial blood flow was 5.0 ml/min and 6.0 ml/min per 100 g tissue in patients receiving ropivacaine and bupivacaine, respectively. After epidural bupivacaine, blood flow increased in 8 of 10 patients to 6.9 ml/min per 100 g tissue (P less than 0.05) in contrast to a decrease in 9 of 10 patients to 3.3 ml/min per 100 g tissue after ropivacaine (P less than 0.05), (P less than 0.01 between groups). The median level of sensory analgesia was T3.5 and T4.5 in the ropivacaine and bupivacaine group, respectively (P greater than 0.05). The demonstrated vasoconstrictor effect of epidural ropivacaine may influence the duration of its local anaesthetic effect.