Rearrangement of integrins in avidity regulation by leukocytes
Rearrangement of integrins in avidity regulation by leukocytes
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DOI：
10.1385/ir:26:1-3:199
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发表时间：
2002-01-01
影响因子：
4.4
通讯作者：
Kucik, DF
中科院分区：
文献类型：
--
作者：
Kucik, DF
白细胞粘附必须严格控制，以便白细胞作为非粘附细胞在体内巡逻，但停止并从血液中迁移到感染或炎症部位的组织中。这个过程中的一个关键因素是β(2)整合素的激活。虽然β(2)整合素的激活涉及构象变化，从而增加对配体的亲和力，但越来越多的证据表明，整合素的重排导致亲和力的增加，至少在调节结合能力方面同样重要。最近的研究已经确定了整合素的扩散和重排对激活白细胞粘附的重要性，并开始揭示其调控的分子基础。
Leukocyte adhesion must be tightly controlled in order for leukocytes to patrol the body as nonadherent cells, yet stop and emigrate from the blood into tissues at sites of infection or inflammation. A key element in this process is activation of beta(2) integrins. While beta(2) integrin activation involves conformational changes that increase affinity for ligand, evidence is accumulating that rearrangement of integrins, resulting in increases in avidity, is at least as important in regulating binding capacity. Recent work has established the importance of diffusion and rearrangement of integrins to activation of leukocyte adhesion, and has begun to unravel the molecular basis of its regulation.