Differences in dyslipidemia between American and Italian women with polycystic ovary syndrome
Differences in dyslipidemia between American and Italian women with polycystic ovary syndrome
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DOI：
10.1007/bf03345564
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发表时间：
2008-01-01
影响因子：
5.4
通讯作者：
Carmina, E.
中科院分区：
文献类型：
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作者：
Essah, P. A.;Nestler, J. E.;Carmina, E.
背景：血脂异常是多囊卵巢综合征（PCOS）常见的代谢并发症。本研究的目的是确定不同种族和地理背景的多囊卵巢综合征女性的血脂异常是否存在差异。方法：本回顾性研究评估了106名美国多囊卵巢综合征女性和108名意大利多囊卵巢综合征女性在内分泌科诊所的空腹血脂特征。结果：美国女性的平均体重指数高于意大利女性（36.1 +/- 8.6 vs 28.1 +/- 5.8 kg/m, p < 0.01）。低高密度脂蛋白胆固醇是两种人群中最普遍的脂质异常。美国妇女的血清总胆固醇、低密度脂蛋白胆固醇和甘油三酯的平均水平较高，而血清高密度脂蛋白胆固醇的平均水平较低。这些差异大多是由于体重的差异。在控制体重和年龄差异后，美国女性的空腹血清甘油三酯仍高于意大利女性[131.1 mg/dI， SE=7.8, 95%可信区间=(115.7,146.5)vs；99.3， SE=8.4, 95%置信区间=(82.9115.8)]。结论：体重的变化本身并不能完全解释不同种族和地理背景的女性血脂异常的差异。遗传和环境因素，如饮食和活动水平，可能导致这些差异。
Background: Dyslipidemia is a common metabolic complication in polycystic ovary syndrome (PCOS). The aim of this study was to determine if differences exist in dyslipidemia in women with PCOS from different ethnic and geographical backgrounds. Methods: This retrospective study evaluated the serum fasting lipid profiles of 106 women with PCOS from the United States and 108 women with PCOS from Italy evaluated at endocrinology clinics. Results: American women had higher mean body mass index than Italian women (36.1 +/- 8.6 vs 28.1 +/- 5.8 kg/m(2), p < 0.01). Low HDL-cholesterol was the most prevalent lipid abnormality in both populations. U.S. women had higher mean levels of serum total cholesterol, LDL-cholesterol, and triglycerides, and lower mean serum HDL-cholesterol. Most of these differences were due to differences in weight. After controlling for differences in weight and age, fasting serum triglycerides remained higher in U.S. women compared with Italian women [131.1 mg/dI, SE=7.8, 95% confidence interval =(115.7, 146.5) vs; 99.3, SE=8.4, 95% confidence interval =(82.9,115.8)]. Conclusions: Variations in body weight alone do not fully explain differences in dyslipidemia in women of diverse ethnic and geographical backgrounds. Genetic and environmental factors, such as diet and activity level, likely contribute to these differences.