B cells and humoral immunity in atherosclerosis.
B cells and humoral immunity in atherosclerosis.
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DOI：
10.1161/circresaha.113.301145
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发表时间：
2014-05-23
影响因子：
20.1
通讯作者：
Binder CJ
中科院分区：
文献类型：
--
作者：
Tsiantoulas D;Diehl CJ;Witztum JL;Binder CJ
深入了解炎症和免疫功能在动脉粥样硬化的发展和进展中的重要作用，大大提高了我们对这种疾病的理解。虽然T细胞的作用已经被广泛研究了几十年，但直到最近，B细胞的作用才得到更多的关注。最近的研究已经确定了不同B细胞亚群的差异效应，并有助于澄清这些作用的机制仍然知之甚少。B1细胞已被证明可以防止病变的形成，而B2细胞已被认为可以促进病变的形成。主要来自B1细胞的天然IgM抗体已被证明可以介导动脉粥样硬化保护作用，但其他免疫球蛋白类，特别是IgG的功能作用仍然是难以捉摸的。在这篇综述中，我们将集中在最近的见解B细胞和各种免疫球蛋白类的作用，以及如何这些可能介导动脉粥样硬化病变形成的影响。此外，我们将强调潜在的治疗方法，重点是B细胞耗竭，可用于将实验证据转化为人类疾病。
Insights into the important contribution of inflammation and immune functions in the development and progression of atherosclerosis have greatly improved our understanding of this disease. Although the role of T cells has been extensively studied for decades, only recently has the role of B cells gained more attention. Recent studies have identified differential effects of different B-cell subsets and helped to clarify the still poorly understood mechanisms by which these act. B1 cells have been shown to prevent lesion formation, whereas B2 cells have been suggested to promote it. Natural IgM antibodies, mainly derived from B1 cells, have been shown to mediate atheroprotective effects, but the functional role of other immunoglobulin classes, particularly IgG, still remains elusive. In this review, we will focus on recent insights on the role of B cells and various immunoglobulin classes and how these may mediate their effects in atherosclerotic lesion formation. Moreover, we will highlight potential therapeutic approaches focusing on B-cell depletion that could be used to translate experimental evidence to human disease.