A review of the developmental and reproductive toxicity of styrene
A review of the developmental and reproductive toxicity of styrene
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DOI：
10.1006/rtph.2000.1406
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发表时间：
2000-12-01
影响因子：
3.4
通讯作者：
Neal, BH
中科院分区：
文献类型：
--
作者：
Brown, HA;Lamb, JC;Neal, BH
苯乙烯的生殖和发育毒性已经在动物和人类身上进行了研究。关于苯乙烯的动物研究有不同的研究设计和结论。已经在大鼠、小鼠、兔子和仓鼠身上进行了发育或生殖毒性研究，在大多数情况下，需要高剂量才能产生影响，而且这种影响并不是生殖或发育所特有的。在一些报告中，要么是实验设计有限，要么是对设计和测量的终点的描述不足以得出关于苯乙烯毒性的结论，更完整和更好的报告表明，在不具有母体毒性的剂量水平上，苯乙烯不会造成发育毒性。据报道，在高暴露条件下，会产生一些神经化学或神经行为影响。苯乙烯不会影响生育或生殖功能。大量关于苯乙烯的动物毒性数据支持这样的结论，即苯乙烯既不是内分泌活性物质，也不是内分泌干扰物。人体研究经常受到暴露数据不足或暴露于多种材料的影响，因此不可能将影响归因于苯乙烯暴露。此外，调查人员在他们的研究中往往没有考虑到工作场所的其他暴露或其他潜在的混杂因素。月经周期异常和先天异常最初被报道；然而，最近更好的报道并没有表明苯乙烯对人类的发育或生殖造成影响。人类研究也支持这一结论，即苯乙烯不是内分泌干扰物，尽管一些研究作者得出结论，苯乙烯是人类或动物的生殖或发育毒物，但仔细审查表明，这种结论是不合理的。(C)2000年学术出版社。
The reproductive and developmental toxicity of styrene has been studied in animals and humans. The animal studies on styrene have diverse study designs and conclusions. Developmental or reproductive toxicity studies have been conducted in rats, mice, rabbits, and hamsters, In most cases, high doses are required to elicit effects, and the effects are not unique to reproduction or development. In a number of the reports, either the experimental designs are limited or the descriptions of the designs and the endpoints measured are insufficient to draw conclusions about the toxicity of styrene, The more complete and better-reported studies show that styrene does not cause developmental toxicity at dose levels that are not maternally toxic. Some neurochemical or neurobehavioral effects have been reported at high exposures. Styrene does not affect fertility or reproductive function. Considerable animal toxicity data on styrene support the conclusion that styrene is neither an endocrine-active substance nor an endocrine disrupter. Human studies often suffer fr-om either inadequate exposure data or exposure to a wide variety of materials, so that attribution of effects to styrene exposure is impossible. Furthermore, investigators often have failed to account for other exposures in the workplace or for other potentially confounding factors in their studies. Menstrual cycle irregularities and congenital abnormalities were initially reported; however, the better and more recent reports do not show that styrene causes developmental or reproductive effects in humans. Human studies also support the conclusion that styrene is not an endocrine disrupter, Although some study authors have concluded that styrene is either a human or an animal reproductive or developmental toxicant, careful review demonstrates that such conclusions are not justified. (C) 2000 Academic Press.