Cyanine Dyes - Nucleic Acids Interactions
Cyanine Dyes - Nucleic Acids Interactions
复制标题
DOI：
10.2174/138527211796367336
复制
发表时间：
2011-08-01
影响因子：
2.6
通讯作者：
Mishra, B. K.
中科院分区：
文献类型：
--
作者：
Dash, S.;Panigrahi, M.;Mishra, B. K.
染料-DNA 相互作用的研究因其在化学和生物测定中的广泛应用而引起了广泛的关注。花青染料由于染料与核酸的结合而导致颜色发生显着变化，因此被广泛用于追踪核酸。染料聚集在 DNA 模板上，并且由此产生的聚集体的光物理特性可用于揭示模板的结构。这些染料与肽核酸的相互作用也引起了人们对揭示许多生化过程的广泛兴趣。
Studies on dye-DNA interaction have attracted considerable attention owing to its wide facet of applications in both chemical and biological assays. Cyanine dyes have been extensively used in tracing nucleic acids due to their significant change in colour due to dye-nucleic acid binding. The dyes aggregate on DNA templates and the resultant photophysical characteristics of the aggregates can be exploited to reveal the structure of the template. Interaction of these dyes with peptide nucleic acid has also generated wide interest for unveiling many biochemical processes.